BACKGROUND Thymosin beta 4 (Tbeta(4)) is a member of beta-thymosins, a family of peptides that play essential roles in many cellular functions. A recent study from our group suggested a role for Tbeta(4) in the development of human salivary glands. The aim of this study was to analyze the expression of Tbeta(4) in the human gut during development, and in the adult. METHODOLOGY/PRINCIPAL FINDI...

Franz J., A. Milon, H. Salmon: Synthesis of Immunoglobulins IgG, IgM and IgA during the Ontogeny of Foetal Pigs. Acta vet. Bmo, 51,1982: 23-30. Using the modified micro-ELISA (enzyme linked immunosorbent assay) on the competitive principle immunoglobulins IgG, IgM and 19A were demonstrated in the blood serum, amniotic fluid and organ suspensions of 50to 150-day old pig foetuses. The predominant...

We have previously reported that (1) the migration of foetal and adult fibroblasts into three-dimensional collagen matrices is differentially affected by cell density, and (2) skin fibroblasts from cancer patients commonly display a foetal-like mode of migratory behaviour. Data presented here indicate that differences in the migration of these cell types are particularly apparent in cultures pl...

Reconstruction of CNS circuitry is a major aim of neural transplantation, and is currently being assessed clinically using foetal striatal tissue in Huntington's disease. Recent work suggests that neuronal precursors derived from foetal striatum may have a greater capacity than primary foetal striatum to project to the usual striatal target areas such as the globus pallidus and substantia nigra...

BACKGROUND Perinatal asphyxia is, even in developed countries, one the major causes of neonatal morbidity and mortality. Therefore, if foetal distress during labour is suspected, one should try to restore foetal oxygen levels or aim for immediate delivery. However, studies on the effect of intrauterine resuscitation during labour are scarce. We designed a randomised controlled trial to investig...

The desire of every women contemplating motherhood is that her pregnancy culminates in a healthy offspring who will achieve the highest possible physical and mental potential. Assessment of the foetal wellbeing is done by various biophysical methods. But the problem of sample collection, accuracy and need for laboratory technology and personnel have made biochemical methods of foetal monitoring...