Secretory carcinoma (SC) is a rare recently described entity that has characteristics similar to those of secretory breast carcinoma. We report case 23 years old male with swelling on the parotid gland. The ultrasonography guided fine needle aspiration cytology was performed mass. Cytologically, background aspirate composed inflammatory cells admixed mucinous material. There were isolated as mu...

Differentiated thyroid carcinoma includes 2 different tumor types, papillary (PC) and follicular carcinoma (FC), and although similar, their prognosis is different. FC is uncommon, and this has led to it often being analyzed together with PC, and therefore the true reality of this tumor is difficult to know. As a result, the diagnostic and therapeutic management and the prognostic factors in di...

Thyroid squamous cell carcinoma is very rare. At present, it limited to case reports. Since the thyroid follicular epithelium non-squamous epithelium, how primary (SCC) of occurs still a controversial issue. Hashimoto’s thyroiditis (HT) considered be an independent risk factor for cancer, under basis HT, tumor cells evolve and develop papillary (PTC), particularly de-differentiate into SCC elus...

Several types of thyroid cancer ± classic papillary, anaplastic and medullary thyroid carcinoma ± can be confidently diagnosed and distinguished through fineneedle aspiration cytology (FNAC) of a thyroid nodule, thanks to their characteristic morphology and additional immunocytochemistry. In contrast, the finding of follicular thyroid neoplasia, a cytological group diagnosis encompassing the th...

PURPOSE Most prognostic systems for differentiated carcinoma have been designed for papillary carcinoma. OBJECTIVE To analyze the value of the existing prognostic systems for evaluating follicular carcinoma and to determine whether any of them have a better predictive effect. METHODS A total of 66 follicular carcinomas were analyzed. The following prognostic systems were studied: EORTC, AGE...

Undifferentiated carcinoma (also known as anaplastic carcinoma) of the thyroid gland is a highly aggressive malignant neoplasm composed of undifferentiated cells that exhibit immunohistochemical or ultrastructural epithelial differentiation. Nearly all patients report a long history of thyroid gland disease, often goiter or Hashimoto thyroiditis. In most cases, there is a transformation from a ...

Introduction Follicular thyroid carcinoma is the second most frequent type of well differentiated thyroid tumours. It is usually confined to the thyroid gland, however it can metastasize in a later stage of the disease. Signs and symptoms associated with bone metastasis are rare as first clinical manifestations. Case report An 84-year-old female complained with acute paraparesis. Magnetic res...

The most common BRAF mutation in thyroid cancer is c.1799T>A (p.Val600Glu), and other BRAF mutations are rarely reported. We investigated the clinicopathological features of thyroid cancer with rare BRAF mutations. A total of 2,763 patients with thyroid cancer underwent molecular testing by direct DNA sequencing for mutations in BRAF exon 15. Among them, 2,110 (76.4%) had BRAF mutations. The c....

AIM To stratify the malignancy risks in thyroid nodules in a tertiary care referral center using the Bethesda system. METHODS From January, 2012 to December, 2014, a retrospective analysis was performed among 1188 patients (15-90 years) who had 1433 thyroid nodules and fine-needle aspiration at Prince Sultan Military Medical City, Saudi Arabia. All thyroid cyto-pathological slides and ultra s...

The molecular biology of follicular cell growth in thyroid nodules is still poorly understood. Because gain-of-function (activating) mutations of the thyroid-stimulating hormone receptor (TShR) and/or Gs alpha genes may confer TSh-independent growth advantage to neoplastic thyroid cells, we searched for somatic mutations of these genes in a series of hyperfunctioning and nonfunctioning follicul...