Cardiovascular diseases, like atherosclerosis, and neurodegenerative diseases affecting the central nervous system (CNS) are closely linked to alterations of cholesterol metabolism. Therefore, innovative pharmacological approaches aiming at counteracting cholesterol imbalance display promising therapeutic potential. However, these approaches need to take into account the existence of biological...

BACKGROUND There is a proliferation of lifestyle-oriented mobile technologies; however, few have targeted users. Through intervention mapping, investigators and community partners completed Steps 1-3 (needs assessment, formulation of change objectives, and selection of theory-based methods) of a process to develop a mobile cancer prevention application (app) for cancer prevention. The aim of th...

BACKGROUND Liberalization and decentralization of public sector has been triggered in some developing countries and in Iran by the Ministry of Health and Medical Education (MOHME) that granted autonomy to 54 public hospitals. However, establishment of such a complex organizational reform was rather unsuccessful. We aimed to explore the obstacles and barriers caused such a failure and their mech...

As from 2001, the Southern African Development Community (SADC) has embarked on a course to deepen regional integration through restructuring. Under the new structure SADC has centralised the coordination of its activities to the Secretariat in Gaborone. The former Sector Coordinating Units have been merged into four directorates, one of which is the Food, Agriculture and Natural Resources (FAN...

The construction sector in India is the government's intense focus on creating a world-class infrastructure balancing environmental conservation. Adopting green procurement practices by mitigating adoption barriers necessary for Indian firms to achieve goal. However, none of existing research identified comprehensive list barriers, analysed their impacts adoption, prioritized and formulated sol...

Ny grønlandsk strategi skal mindske verdens højeste selvmordsrate. Den nye strategi har særligt fokus på forebyggelse af selvmord blandt unge. Opvækst i familier med alkohol og seksuelle overgreb gør grønlandske unge særligt udsatte. Antallet af selvmord i Grønland er målt i forhold til indbyggertallet verdens højeste. I 2010 blev der begået 62 selvmord på Grønland – hvilket giver landet en sel...

Background: Adolescence is an important period in human life and the low-level access of adolescents to reproductive and sexual health services is a concern because preventive, diagnostic and therapeutic services are needed for healthy sexual and reproductive behaviors. This study was conducted with the aim of considering the barriers against adolescent access to repro...

*Corresponding author: Dr. Asghar Mesbahi, Department of Medical Physics, Medical School, Tabriz university of Medical Sciences, Tabriz, Iran. Fax: +98 411 3364660 E-mail: [email protected] Background: Designing and shielding of an appropriate radiography room has been one of the major concerns of radiation scientists since the first decade after the invention of X-rays. Recently, report ...

Chapter 1 describes the barriers that have hindered the effective use of gene delivery and a literature review of methods designed to overcome those barriers. Areas of gene delivery that will be discussed include viral, physical, and non-viral methods of gene delivery. A special focus will be on methods to target gene delivery vehicles and more specifically the somatostatin receptor 2 (SSTR2) t...