Endothelial progenitor cells (EPCs) have great clinical value because they can be used as diagnostic biomarkers and as a cellular therapy for promoting vascular repair of ischaemic tissues. However, EPCs also have an additional research value in vascular disease modelling to interrogate human disease mechanisms. The term EPC is used to describe a diverse variety of cells, and we have identified...

Over the last decades or so, artificial neural networks (ANNs) have become one of the most promising tools for modelling hydrological processes such as rainfall-runoff processes. In most studies, ANNs have been demonstrated to show superior result compared to the traditional modelling approaches. They are able to map underlying relationships between input and output data without detailed knowle...

The purpose of this paper is to use the framework of hidden Markov chains for the modelling of the failure and debugging process of software, and the prediction of software reliability. The model parameters are estimated using the forward-backward EM algorithm and model selection is done with the BIC criterion. The advantages and drawbacks of this approach with respect to usual modelling are an...

This paper presents a novel method of creating and updating geographical population microdata. In particular, it presents a prototype modelling technique which forms a component of the SimBritain modelling project. The paper first briefly discusses some of the key conceptual and practical issues involved in microsimulation, in particular highlighting the differences between spatial and aspatial...

Fluvial point-bar evolution commonly involves multiple stages of bar development driven by changes in the style meander transformations. Complicated planform morphologies are widely recognized remote-sensing imagery, but relationships between meander-bend evolutionary behaviour and stratigraphic architecture, facies distribution, sand volumes remain poorly understood. This study applies a geome...

An automated method of modelling the electrical properties of the human thorax from horizontal section data such as computerized tomographic scans has been used to develop both forward and inverse transformations between epicardial and body surface potential distributions. Eleven torso models with varying geometry and organ configurations have been studied. For the forward calculations, a stand...