PURPOSE It is not known whether the prostaglandin FP receptor plays an important role in endogenous 24-hour regulation of intraocular pressure. The purpose of this study was to compare 24-hour intraocular pressure (IOP) in FP receptor-knockout mice with that of wild-type mice that have normal FP receptor expression. METHODS The 24-hour IOP profile was determined by rebound tonometry in FP-kno...

Combinations of drugs with distinct and complementary mechanisms of action may offer improved efficacy in the treatment of chronic obstructive pulmonary disease (COPD). In two 12-week, double-blind, parallel-group studies, patients with COPD were randomized 1:1:1 to once-daily umeclidinium (UMEC; 62.5 μg and 125 μg) or placebo (PBO), added to twice-daily fluticasone propionate/salmeterol (FP/SA...

iran’s significant success in implementing family planning (fp) during the past 25 years, has made it a role model in the world. the total fertility rate (tfr) in iran has dropped from 6.5 in 1960 to 1.6 in 2012, which is well below the targeted value of 2.2 for the country. iran’s success story, however, did not merely root in the implementation of fp programs. in other words, families’ strong...

this paper presents a new formulation for warehouse inventory management in a stochastic situation. the primary source of this formulation is derived from fp model, which has been proposed by fletcher and ponnambalam for reservoir management. the new proposed mathematical model is based on the first and the second moments of storage as a stochastic variable. using this model, the expected value...

The electronic structure of SrBi 2 Ta 2 O 9 is investigated from first-principles, within the local density approximation, using the full-potential linearized augmented plane wave (LAPW) method. The results show that, besides the large Ta(5d)-O(2p) hybridization which is a common feature of the ferroelectric perovskites, there is an important hybridization between bismuth and oxygen states. The...

INTRODUCTION Pressurized metered-dose inhalers (pMDI) such as fluticasone propionate and salmeterol (FP/SAL) are commonly used for the treatment of asthma in the UK. Previously, a budget impact analysis demonstrated that use of FP and formoterol fumarate (FP/FORM) pMDI as an alternative to FP/SAL pMDI, would be a cost-saving option for the UK National Health Service (NHS). This budget impact an...