نتایج جستجو برای: fractional exhaled nitric oxide
تعداد نتایج: 241546 فیلتر نتایج به سال:
Machado, Roberto F., James K. Stoller, Daniel Laskowski, Shuo Zheng, Joseph A. Lupica, Raed A. Dweik, and Serpil C. Erzurum. Low levels of nitric oxide and carbon monoxide in 1-antitrypsin deficiency. J Appl Physiol 93: 2038–2043, 2002. First published August 30, 2002; 10.1152/japplphysiol.00659.2002.—Quantitations of exhaled nitric oxide (NO) and carbon monoxide (CO) have been proposed as noni...
BACKGROUND The clinical phenotypes and underlying mechanisms of asthma-COPD overlap syndrome (ACOS) remain elusive. This study aimed to investigate a comparison of COPD patients with and without ACOS, focusing on inflammatory biomarkers, in an outpatient COPD cohort. METHODS We conducted a cross-sectional study analyzing prospectively collected data from the Ishinomaki COPD Network registry. ...
BACKGROUND Increased production of nitric oxide (NO) by the lower respiratory tract is viewed as a marker of airway inflammation in asthma and bronchiectasis. NO is a potentially important immune modulator, inhibiting the release of several key pro-inflammatory cytokines. As sarcoidosis is characterised by granulomatous airway inflammation, we hypothesised that exhaled NO levels might be raised...
BACKGROUND Caffeine is known to inhibit phosphodiesterases, to mobilise intracellular calcium, and to act as an antagonist at adenosine receptors, all of which can potentially alter nitric oxide (NO) production. It was therefore hypothesised that caffeine may alter exhaled NO (eNO) levels. METHODS In a randomised, single blind, crossover manner, 12 normal subjects consumed either (1) coffee a...
Air pollution has recently been associated with the development of acute decompensated heart failure, but the underlying biological mechanisms remain unclear. A pulmonary vasoconstrictor effect of air pollution, combined with its systemic effects, may precipitate decompensated heart failure. The aim of the present study was to investigate the effects of acute exposure to diesel exhaust (DE) on ...
BACKGROUND Strenuous physical activity at an elite level is associated with an increased risk for asthma and, in some sports, also prevalence of allergies. The aim of this study was to investigate the prevalence of asthma and allergy among elite swimmers and tennis players and compare airway hyperreactivity to mannitol and exercise. MATERIALS AND METHODS One hundred and one adolescent swimmer...
Much interest is now being focused on measurements of nitric oxide (NO) in exhaled air. In healthy subjects exhaled NO seems to originate mainly in the nasal airways, whereas the contribution from the lower respiratory tract is low. In certain inflammatory airway disorders, the excretion of NO into the airways is altered resulting in changes in the levels of NO in exhaled air. New techniques ha...
RATIONALE Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. OBJECTIVES Using transcriptomic profiling of airway tissues, we sought to define the molecular phenotypes of severe asthma. METHODS The transcriptome derived from bronchial biopsies and epithelial brushings of 107 subjects with moderate to severe asthma were annotated by gene set variation...
In humans, respiratory disorders are common. Today, rapid, risk-free, and potentially low-cost diagnostics of detected in the patient's exhaled air critical. Fractional nitric oxide (FENO), volatile organic molecules, carbon monoxide, hydrocarbons, hydrogen peroxide among inhaled biomarkers mentioned. Breathomics from compounds oximeters also shortly discussed. The use WO3 FENO monitors is They...
We were interested to read the paper by LEHTIMÄKI et al. [1] recently published in the European Respiratory Journal, in which those authors reported that ‘‘high pre-treatment levels of J9aw,NO [bronchial nitric oxide flux] are related to symptom relief and improvement of airway obstruction’’ when inhaled fluticasone is given to patients with chronic obstructive pulmonary disease (COPD). Their d...
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