objective(s): recently, phthalimide derivatives were designed based on ameltolide and thalidomide as they possess a similar degree of anticonvulsant potency due to their phenytoin-like profile. the ability of phthalimide pharmacophore to interact with neuronal voltage-dependent sodium channels was studied in the batrachotoxin affinity assay. therefore, in the present study, a series of 19 compo...

In this article, we consider Stokes’ first problem for a heated generalized second grade fluid with fractional derivative (SFP-HGSGF). Implicit and explicit numerical approximation schemes for the SFP-HGSGF are presented. The stability and convergence of the numerical schemes are discussed using a Fourier method. In addition, the solvability of the implicit numerical approximation scheme is als...

We discuss the impact of different solar neutrino data on the spin-flavor-precession (SFP) mechanism of neutrino conversion. We find that, although detailed solar rates and spectra allow the SFP solution as a subleading effect, the recent KamLAND constraint on the solar antineutrino flux places stronger constraints on this mechanism. Moreover, we show that for the case of random magnetic fields...

The cyclic-imide-hydrolyzing activity of a prokaryotic cyclic-ureide-hydrolyzing enzyme, D-hydantoinase, was investigated. The enzyme hydrolyzed cyclic imides with bulky substituents such as 2-methylsuccinimide, 2-phenylsuccinimide, phthalimide, and 3,4-pyridine dicarboximide to the corresponding half-amides. However, simple cyclic imides without substituents, which are substrates of imidase (i...

One purpose of the present study was to evaluate the ability of 7-wk-old spontaneously hypertensive rats (SHR) to reset tubuloglomerular feedback (TGF) activity in response to acute volume expansion (VE). Second, we evaluated the contribution of ANG II, via its action on AT1 receptors, to TGF control of glomerular function during VE. TGF was assessed by micropuncture methods and proximal tubula...

PURPOSE To evaluate the effects of two cycles of vagus nerve stimulation (VNS), 30 s/5 min and 7 s/18 s on the interictal epileptiform discharges (IEDs). METHODS Twenty patients were studied, 12 with generalized and 8 with partial seizures. An EEG of 120 channels was performed during 3 different conditions, each one lasting 30 min: basal state (BS), 30 s/5 min and 7 s/18 s VNS cycles. The num...

BACKGROUND Adolescents' alcohol consumption is a public health concern in Sweden as well as in many other countries. Underage drinking is associated with increased risks of alcohol-related injuries, risky sexual behaviours and dependence later in life. Different strategies have been used in the effort to prevent this behaviour, and to postpone the onset of alcohol. The Strengthening Families Pr...

A lot of effort has been spent to prevent the occurrence SA in nuclear plant and develop Severe Accidents (SA) Management mitigate consequences a SA. Those are mainly related limit release fission product environment. The core vessel is not only source products as Spent Fuel Pool (SFP) hosting fuel removed by is, some NPP, inside containment conditions can also occur. This especially important ...

A mild catalyst system for the synthesis of chiral amino alcohols via asymmetric transfer hydrogenation (ATH) of α-phthalimide ketones has been developed by using a chiral Ru-TsDPEN complex as the catalyst in DMF/MeOH at 40 °C. The reaction exhibits high reaction activity and excellent enantioselectivity where up to 96% yield and 99% ee of the product were obtained.