The adenosinergic system is involved in many important physiological functions. Adenosine exerts its extracellular effects through four types of G-protein-coupled receptors: A(1), A(2A), A(2B) and A(3). Adenosine acts as an important regulator of metabolic processes. In the brain adenosine mediates prominent neuroprotective functions via the adenosine A(1) receptor. Whereas the pharmacological ...

1 AbstractThe estimation of time-varying instantaneous frequency for monocomponent signals with incomplete set of samples is considered. A suitable time-frequency distribution reduces the nonstationary signal into a local sinusoid over the lag variable prior to Fourier transform. Accordingly, the observed spectral content becomes sparse and suitable for compressive sensing reconstruction in the...

This paper proposes a simple and efficient approach for the optimal dispatch in a medium-voltage microgrid (MG) with various types of distributed generation (DG). The fuel costs generated by these DGs are determined using quadratic and linear functions dependent on the types of DGs. Instead of using the traditional Lagrange multiplier method for power system economic dispatch, the proposed dire...

Eosinophils are potent effector cells implicated in allergic responses and helminth infections. Responding to stimuli, they release their granule-derived cytotoxic proteins and are involved in inflammatory processes. However, under homeostatic conditions, eosinophils are abundantly present in the intestine and are constantly in contact with the gut microbiota and maintain the balance of immune ...

We propose a method of wavelength multiplexing based on a modified Gerchberg-Saxton algorithm (MGSA) and a cascaded phase modulation scheme in the Fresnel transform domain to reduce the cross talk in the multiple-image-encryption framework. First, each plain image is encoded to a complex function by using the MGSA. Next, the phase components of the created complex functions are multiplexed with...

Various sequences that possess explicit analytic expressions can be analysed asymptotically through integral representations due to Lindelöf, which belong to an attractive but largely forgotten chapter of complex analysis. One of the outcomes of such analyses concerns the non-existence of linear recurrences with polynomial coefficients annihilating these sequences, and, accordingly, the non-exi...

T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young's modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune ...

Natural killer (NK) cells were originally identified as lymphocytes capable of killing cancer cells without prior sensitization (1). Further characterization of these cells in both humans and rodent models has expanded their role towards a broad-based immunosurveillance of diseased and healthy peripheral tissues. Among peripheral organs, the lung contains the largest percentage of NK cells. Acc...

With the more sophisticated abilities of teams within the simulation league high level online functions become more and more attractive. Last year we proposed an approach to recognize the opponents strategy and developed the online coach accordingly. However, this approach gives only information about the entire team and is not able to detect significant situations (e.g. double pass, standard s...

Cancer cells can adapt and survive under low nutrient conditions, but underlying mechanisms remain poorly explored. We demonstrate here that glucose maintains a functional complex between the co-chaperone URI, PP1γ, and OGT, the enzyme catalyzing O-GlcNAcylation. Glucose deprivation induces the activation of PKA, which phosphorylates URI at Ser-371, resulting in PP1γ release and URI-mediated OG...