BACKGROUND AND PURPOSE Patent foramen ovale (PFO) has been identified as a potential risk factor for cerebrovascular ischemia. Procoagulant mutations may increase the risk and impact the choice of appropriate therapy for secondary prevention. We evaluated the prevalence of the 2 most common genetic risk factors for thromboembolism, factor V Leiden (G1691A) and prothrombin G20210A, in young PFO ...

BACKGROUND Emerging perioperative genomics may influence the direction of risk assessment and surgical strategies in cardiac surgery. The aim of this study was to investigate whether single nucleotide polymorphisms (SNP) affect the clinical presentation and predispose to increased risk for postoperative adverse events in patients undergoing coronary artery bypass grafting surgery (CABG). METH...

INTRODUCTION Osteonecrosis (ON) of the femoral head (ONFH), a debilitating bone disease characterized by cellular death in the bone tissue, can lead to collapse of the architectural bony structure and joint function loss. Although many conditions, such as steroids, alcoholism, coagulation defects, storage diseases, marrow-infiltrating diseases, and some autoimmune diseases, can increase the ris...

Thrombophilia is a multigenic disease in which the combination of genetic polymorphisms increases the risk of deep vein thrombosis (DVT). The rapid identification of these genetic combinations requires high-throughput analysis of single nucleotide polymorphisms (SNPs). The TaqMan fluorogenic 5'-->*3' nuclease assay (PE/Applied Biosystems, Foster City, CA) with custom-designed primers, probes an...

After a first episode of spontaneous venous thromboembolism (VTE), the risk of recurrence persists for many years. However, comprehensive data about the risk of recurrence in pediatric patients have hitherto not been reported. Thus, this study evaluated the risk of recurrent VTE among children in relation to the presence of single or combined-inherited and/or acquired causes of thrombophilia. A...

To better understand potentially reversible causes of idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, and an apparent association of IIH with polycystic-ovary syndrome (PCOS), we assessed associations of IIH with coagulation disorders and with PCOS in 38 women with well-documented IIH. Fifteen women were found to have PCOS; 14 of them were obese, with a body-mass ...

Background . Acute ischemic cerebral circulation disorder and myocardial infarction occupy one of the first places among causes postoperative mortality in patients with malignant tumors thoracoabdominal localization. The issue role molecular genetic factors cardiovascular risk development these complications has not been resolved at present. Objective To analyze effect polymorphisms hemostasis ...

BACKGROUND The thrombin-generation assay has a variety of clinical uses, including diagnosis of thromboembolism-related disease, and particular profiles are associated with thrombophilic risk factors. The aim of this study was to evaluate the use of this assay in screening and identifying patients who require specific thrombophilic testing. METHODS We used a 2-step approach to perform specifi...

storage of blood at room temperature is uncertain, but one possibility is that cleavage of the antigen occurs, releasing smaller fragments, each with multiple OVX1 epitopes. Different cutoffs at 7.2, 10.5, or 12.1 kilounits/L have been used in clinical studies (2, 4). The present findings, therefore, are clinically relevant because the assay range is narrow and the effect we have noted can caus...

Abstract STUDY QUESTION Is there an association between hereditary thrombophilia in pregnant women and risk of recurrent pregnancy loss (RPL)? SUMMARY ANSWER Pregnant with have increased RPL, especially for the G1691A mutation factor V Leiden (FVL) gene, G20210A prothrombin gene (PGM), deficiency protein S (PS). WHAT IS KNOWN ALREADY Prior studies suggested that a higher however, results are in...