We consider a model for neutralino dark matter candidates arising in anomaly-mediated supersymmetry breaking schemes, and examine its testability through the search for exotic cosmic rays produced by neutralino pair annihilations in the dark halo of the Galaxy. We find that the model is already constrained by available antiprotons and positrons measurements and may be further tested in upcoming...

Mice (GR-i) bearing a transgene encoding a glucocorticoid receptor (GR) antisense RNA under the control of a neuron-specific neurofilament promoter were used to investigate the effects of a 4 week chronic mild stress (CMS) on the hypothalamo-pituitary-adrenocortical (HPA) axis and the serotoninergic system in a transgenic model of vulnerability to affective disorders. GR-i mice showed a decreas...

With the aim of analyzing their protective function against chilling-induced injury, the pools of glutathione and its precursors, cysteine (Cys) and gamma-glutamyl-Cys, were increased in the chilling-sensitive maize (Zea mays) inbred line Penjalinan using a combination of two herbicide safeners. Compared with the controls, the greatest increase in the pool size of the three thiols was detected ...

The mechanisms by which a primary tumor affects a selected distant organ before tumor cell arrival remain to be elucidated. This report shows that Gr-1+CD11b+ cells are significantly increased in lungs of mice bearing mammary adenocarcinomas before tumor cell arrival. In the premetastatic lungs, these immature myeloid cells significantly decrease IFN-gamma production and increase proinflammator...

Clusters of galaxies have not yet been detected at gamma-ray frequencies; however, the recently launched Fermi Gamma-ray Space Telescope, formerly known as GLAST, could provide the first detections in the near future. Clusters are expected to emit gamma rays as a result of (1) a population of high-energy cosmic rays fueled by accretion, merger shocks, active galactic nuclei and supernovae, and ...

In this research, the fabrication of transparent Alumina was done by spark plasma sintering (SPS). Two types alpha and gamma powders with particle size 200 50 nm were used, respectively. The assisted materials used in research magnesium nitrate lanthanum nitrate, each which 100 ppm using a chemical precipitation process. Calcination performed at 800°C resulting subjected to SPS 1500 °C rate °C/...

Structured jets are recently invoked to explain the complex emission of gamma ray bursts, such as GW 170817. Based on accretion simulations, expected have a structure that is more than simple top-hat. Also, launching regions blazar should influence their large scale evolution. This revealed by interactions jet components in TXS 0506+056, where observed at viewing angle close zero. Observational...

Glucocorticoid (GC) insensitivity represents a profound challenge in managing patients with asthma. The mutual inhibition of transcriptional activity between GC receptor (GR) and other regulators is one of the mechanisms contributing to GC resistance in asthma. We recently reported that interferon regulatory factor (IRF)-1 is a novel transcription factor that promotes GC insensitivity in human ...