BACKGROUND The combination of a radioisotope with a chemotherapeutic agent in a liposomal carrier (ie, Indium-111-labeled polyethylene glycol pegylated liposomal vinorelbine, [(111)In-VNB-liposome]) has been reported to show better therapeutic efficiency in tumor growth suppression. Nevertheless, the challenge remains as to whether this therapeutic effect is attributable to the combination of a...

This paper applies a recently developed optimization method to examine the design of networks that monitor radiation under routine conditions. Annual gamma dose rates were modelled by combining regression with interpolation of the regression residuals using spatially exhaustive predictors and an anisotropic variogram of the residuals. Locations of monitoring stations were optimized by minimizin...

Heat shock protein 60s (hsp60) are remarkably immunogenic, and both T-cell and antibody responses to hsp60 have been reported in various inflammatory conditions. To clarify the role of hsp60 in T-cell responses in periodontitis, we examined the proliferative response of peripheral blood mononuclear cells (PBMC), as well as the cytokine profile and T-cell clonality, for periodontitis patients an...

Abstract The most commonly used regression model in general insurance pricing is the compound Poisson with gamma claim sizes. There are two different parametrizations for this model: Poisson-gamma parametrization and Tweedie’s parametrization. Insurance industry typically prefers We review both parametrizations, provide new results that help to lower computational costs parameter estimation wit...

In this study, in vitro gas production values (hour/ml) of standard, alfalfa and corn plants at 3, 6, 9, 12, 24, 36, 48, 72 96 hours Kahramanmaras Sutcu Imam University Animal Science Department Feeds Nutrition Laboratory. ) used cubic piecewise regression, Richard, Logistics, Gamma, Gompertz, Orscov, Sigmoaidal Quadratic Piecewise Regression models were used. the modeling mean squares error, d...

The morphology of haloes inform about both cosmological and galaxy formation models. We use the Minkowski Functionals (MFs) to characterize actual haloes, only partially captured by smooth density profile, going beyond spherical or ellipsoidal symmetry. employ semi-analytical with NFW $\alpha\beta\gamma$-profile shape obtain a clear interpretation MFs as function inner outer slope, concentratio...

The peroxisome proliferator-activated receptors (PPAR) are nuclear receptors that regulate gene expression in response to ligand binding. Three PPAR receptor subtypes, namely gamma, alpha and delta (beta), have been identified. The development of PPAR agonist pharmaceuticals for the treatment of type 2 diabetes, dyslipidemia, and obesity is currently an area of great interest. The FDA has recei...

Gene expression analysis previously revealed a robust IFN-responsive gene induction profile that was selectively up-regulated in Borrelia burgdorferi-infected C3H mice at 1 wk postinfection. This profile was correlated with arthritis development, as it was absent from infected, mildly arthritic C57BL/6 mice. In this report we now demonstrate that profile induction in infected C3H scid mice occu...

Anaferon, released-active from of antibodies to interferon-gamma, is an antiviral drug with immunomodulating activity. The long-term experience proved its efficacy and safety in the treatment and prophylaxis of a wide spectrum of viral and bacterial infections. The key mechanisms of anaferon action are the regulation of endogenous interferons, in particular interferon-gamma: induction conformat...

In this paper, we carry out an in-depth theoretical investigation for Bayesian inference for the Cox regression model (Cox, 1972, 1975). Specifically, we establish establish necessary and sufficient conditions for posterior propriety of the regression coefficients, β, in Cox’s partial likelihood, which can be obtained as the limiting marginal posterior distribution of β through the specificatio...