Virus attachment to cells plays an essential role in viral tropism and disease. Reovirus serotypes 1 and 3 differ in the capacity to target distinct cell types in the murine nervous system and in the efficiency to induce apoptosis. The binding of viral attachment protein sigma1 to unidentified receptors controls these phenotypes. We used expression cloning to identify junction adhesion molecule...

In this issue of Neuron, Redmond et al. (2016) identify junction adhesion molecule 2 (JAM2) as an inhibitor of somatodendritic myelination in spinal cord neurons, thereby elucidating how myelin forms on axons but avoids dendrites and cell bodies.

The minaret and archaeological remains at Jam, in central Afghanistan, were nominated as Afghanistan's first World Heritage site in 2002. The nomination was successful despite the International Council on Monuments and Sites (ICOMOS)'s reservations about the quality and completeness of the nomination document: in particular, ICOMOS was concerned about the rudimentary mapping and imprecise defin...

The high-energy particle transport code NMTC/JAM, which has been developed at JAERI, was improved for the high-energy heavy ion transport calculation by incorporating the JQMD code, the SPAR code and the Shen formula. The new NMTC/JAM named PHITS (Particle and Heavy-Ion Transport code System) is the first general-purpose heavy ion transport Monte Carlo code over the incident energies from sever...

Proteases commit microbicide hite blood cells use proteases to kill their targets, according to new results from Emer Reeves, Hiu Lu, Anthony Segal (University College, London, England), and colleagues. The findings contradict previously accepted notions that reactive oxygen species (ROSs) are the killing agents. ROSs like superoxide are produced by NADPH oxidase activity when white blood cells...

yield gap analysis provides an essential framework to prioritize research and policy efforts aimed at reducing yield constraints. to identify options for increasing chickpea yield, the ssm-chickpea model was parameterized and evaluated to analyze yield potentials, water limited yields and yield gaps for nine regions representing major chickpea-growing areas of razavi khorasan province. the aver...

We generate jammed packings of monodisperse circular hard-disks in two dimensions using the Torquato-Jiao sequential linear programming algorithm. The packings display a wide diversity of packing fractions, average coordination numbers, and order as measured by standard scalar order metrics. This geometric-structure approach enables us to show the existence of relatively large maximally random ...