نتایج جستجو برای: gap junction protein beta 2
تعداد نتایج: 3688275 فیلتر نتایج به سال:
background: gap-junctional intercellular communication (gjic) is implicated in physicological processes and it is vitally important for granulosa cell (gc) differentiation and oocyte growth. we investigated the expression of connexin 43 (cx43), a gap junctional protein, in normal and androstenedione-induced polycystic ovary (pco), the effects of androstenedione on cx43 expression, gjic and prog...
Overactive bladder is a highly prevalent clinical condition that is often caused by bladder outlet obstruction (BOO). Increased coupling of bladder smooth muscle cells (BSMC) via gap junctions has been hypothesized as a mechanism for myogenic bladder overactivity in BOO, although little is known about the regulatory system underlying such changes. Here, we report the involvement of basic fibrob...
Specific mutations in GJA1, the gene encoding the gap junction protein connexin43 (Cx43), cause an autosomal dominant disorder called oculodentodigital dysplasia (ODDD). Here, we characterize the effects of 8 of these mutations on Cx43 function. Immunochemical studies have shown that most of the mutant proteins formed gap junction plaques at the sites of cell-cell apposition. However, 2 of the ...
The cells of all tissues are coupled by gap junctions, with the exception of blood and adult skeletal muscle cells. Gap junctions provide for homoeostasis and integrative function by mediating the exchange of ions and chemical second messenger molecules between adjacent cells. The electrical signaling provided by these specialized intercellular junctions is perhaps best understood in the heart,...
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