Electron capture dissociation (ECD) of doubly protonated hyperbranched polyesteramide oligomers (1100-1900 Da) was examined and compared with the structural information obtained by low energy collisionally activated dissociation (CAD). Both the ester and amide bonds of the protonated species were cleaved easily upon ECD with the formation of odd electron (OE(.+)) or even electron (EE(+)) fragme...

Program Number: 991 Poster Board Number: A0380 Presentation Time: 3:15 PM–5:00 PM Corneal Endothelial Cell Density in Ametropic Children and Adolescents Nicholas Faron1, James Hoekel1, Lawrence Tychsen1, 2. 1Ophthalmology, Washington Univ Sch of Med, St Louis, MO; 2Pediatrics, Washington Univ Sch of Med, St. Louis, MO. Purpose: Endothelial cell density (ECD) is known to decrease with age in adu...

Human immunodeficiency virus type 1 (HIV-1) binds to the human CD4 (hCD4) and a coreceptor to enter permissive human cells. The chemokine receptors, hCCR5 and hCXCR4, are the primary coreceptors used by HIV-1 isolates in vivo, however, hCCR3 has been implicated as a coreceptor for HIV infection of the central nervous system. To determine the domains and amino acids important in hCCR3 coreceptor...

PURPOSE We explored the relationship between circulating HER2 extracellular domain (ECD) and tissue HER2 status as determined by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). We also examined its predictive value in a cohort of metastatic breast cancer patients treated with weekly trastuzumab and paclitaxel. METHODS Eligible patients had pre- and post-treatment sto...

Purpose: To study the expression and function of a novel cell cycle regulatory protein, human ecdysoneless (Ecd), during pancreatic cancer (PC) pathogenesis. Experimental Design: Immunohistochemical expression profiling of Ecd was done in nonneoplastic normal pancreatic tissues and pancreatic ductal adenocarcinoma lesions (from tissue microarray and Rapid Autopsy program) as well as precancerou...

UNLABELLED 99mTc-ethylcysteinate dimer (99mTc-ECD) SPECT imaging reportedly fails to show reflow hyperemia in patients with subacute stroke. This study attempts to determine the clinical usefulness of dynamic 99mTc-ECD SPECT in evaluating regional blood flow in subacute cerebral infarction and the kinetic behavior of 99mTc-ECD in infarct areas. METHODS 133Xe and consecutive dynamic and static...

EECD is a non-Langerhans histiocytosis first described by Chester as “lipoidgranulomatose” in 1930.2 By 2010, only 350 additional cases had been added to the literature.3 Patients with ECD typically develop characteristic multifocal osteosclerotic lesions of long bones and may also develop extraskeletal histiocytic infiltrates of other sites including pituitary, orbit, retroperitoneum, kidneys,...

Erdheim-Chester Disease (ECD) is a rare form of non Langerhans' cell histiocytosis. Individuals affected by this disease are typically adults between their 5th and 7th decades of life. Males and females are almost equally affected. The multi systemic form of ECD is associated with significant morbidity, which may arise due to histiocytic infiltration of critical organ systems. Among the more co...

OBJECTIVE Stimulation in early childhood can alleviate adverse effects of poverty. In a community-randomised trial, we implemented 2 home-based interventions, each serving as an attention control for the other. One group received an integrated household intervention package (IHIP), whereas the other group received an early child development (ECD) intervention. The primary objective of the study...