OBJECTIVE Few studies have determined the effects of more than 5-10 years of GH replacement in adults on bone mineral content (BMC) and bone mineral density (BMD). DESIGN/PATIENTS In this prospective, single-centre, open-label study, the effects of 15 years of GH replacement on BMC and BMD, measured using dual-energy X-ray absorptiometry, were determined in 126 hypopituitary adults (72 men) w...

BACKGROUND Prophylactic interventions against osteoporosis require a determination of the factors that influence the accumulation of bone mass during growth. OBJECTIVE The objective was to determine the independent sex-specific contribution of lean mass and fat mass to bone mineral content (BMC), after adjustment for anthropometric variables and lifestyle factors, in healthy children and adol...

OBJECTIVE The objective of this study is to investigate the effect of passive smoking during pregnancy and associated with swimming on bone area growth, bone mineral density (BMD), and bone mineral content (BMC). METHODS The offspring was grouped by control matrices (G1) and passive smokers (G2). The offspring was regrouped in eight subgroups, with exposure to smoking (2x/day) and physical ex...

Previous studies have identified 63 single-nucleotide polymorphisms (SNPs) associated with bone mineral density (BMD) in adults. These SNPs are thought to reflect variants that influence bone maintenance and/or loss in adults. It is unclear whether they affect the rate of bone acquisition during adolescence. Bone measurements and genetic data were available on 6397 individuals from the Avon Lon...

PURPOSE This study evaluated whether a combined behavioral and dietary intervention would affect young women's calcium intake and bone mineral content (BMC). DESIGN The design was a two by three mixed design with one between-subjects factor (treatment vs. control) and one within-subjects factor (time--baseline, 3-month, and 6-month). SETTING The study was conducted in a university setting i...

OBJECTIVE The link between central adiposity and osteopenia has not been extensively studied in Latina women. In particular, the association between abdominal weight and bone mineral content (BMC) and bone mineral density (BMD), independent of total weight and aerobic capacity, remains uncertain, especially in overweight and obese individuals. METHODS Trunk weight, total body fat mass, fat-fr...

Newer bone densitometers using dual-photon absorptiometry (DPA) or dual energy x-ray absorptiometry (DEXA) are capable of measuring the total-body bone mineral; regional analysis of these scans would have significant utility if adequate precision were possible. This study investigated short term precision by weekly scanning (three to five times) normal subjects (total 48 scans) and long term pr...

OBJECTIVE Research on the skeletal status of pre-diabetic (type 2 diabetic) children is warranted. We examined the hypothesis that bone mineral content (BMC) and bone mineral density (BMD) will be lower in children with impaired glucose tolerance (IGT) versus normal glucose tolerance (NGT). RESEARCH DESIGN AND METHODS Total body BMC and BMD of 184 overweight Latino children (106 boys, 78 girl...

It is important to identify risk factors for low bone mass at a young age. An influence of iron store on bone health in the general population has been reported but has not been studied in adolescents. This study aimed to investigate the relationship between hemoglobin and serum ferritin levels and bone mineral content (BMC) in South Korean adolescents.This study was based on data collected dur...

OBJECTIVES Compared with multirow detector CT (MDCT), specimen (ex vivo) micro-CT (μCT) has a significantly higher (~ 30 x) spatial resolution and is considered the gold standard for assessing bone above the cellular level. However, it is expensive and time-consuming, and when applied in vivo, the radiation dose accumulates considerably. The aim of this study was to examine whether the lower re...