The timely clearance of apoptotic neutrophils from inflammation sites is an important function of macrophages; however, the role of macrophages in maintaining neutrophil homeostasis under steadystate conditions is less well understood. By conditionally deleting the antiapoptotic gene cellular FLICE-like inhibitory protein (C-FLIP) in myeloid cells, we have generated a novel mouse model deficien...

The present study aimed at investigating the beneficial effects of co-administering granulocyte colony–stimulating factor (G-CSF) and stem cell factor (SCF) in a model of chronic liver injury induced by thioacetamide (TAA). Biochemical and histopathologycal examinations were performed on serum and liver specimens. At the end of the treatment period, the rats were anesthetized with ether, serum ...

Stem cells have become the fundamental element in regenerative medicine due to their inherent potential to differentiate into various cell types, and the ability to produce various bioactive molecules, including growth factors, cytokines and extracellular matrix molecules. In vivo, the secretion of tropic factors is modulated by chemotactic and inflammatory factors. In this study, we analysed t...

Interleukin-1 alpha (IL-1α) is constitutively expressed in epithelial cells located at barrier sites, such as skin, lung and gut. Upon cellular death, injury or infection, IL-1α released. Serum levels of are largely undetectable healthy volunteers (HV), atopic dermatitis (AD) hidradenitis suppurativa (HS) patients, while the especially epidermis exudates from HS tunnels, highly concentrated. Be...

Interleukin-1 alpha (IL-1α) is constitutively expressed in epithelial cells located at barrier sites, such as skin, lung, and gut. Upon cellular death, injury or infection, IL-1α released. Serum levels of are largely undetectable healthy volunteers (HV), atopic dermatitis (AD) hidradenitis suppurativa (HS) patients, while the especially epidermis exudates from HS tunnels, highly concentrated. B...

Alzheimer’s disease (AD) is a devastating neurodegenerative disease with no current cure. FDA approved drugs have been widely used to address symptoms of AD, but none have been successful in preventing or reversing its effects. As the prevalence of AD increases due to the increased lifespan of the population, it is becoming essential to discover new drugs or find alternative treatment approache...