objective(s):from the ancient era, emergence of agriculture in the connecting region of mesopotamia and the iranian plateau at the foothills of the zagros mountains, made iranian gene pool as an important source of populating the region. it has differentiated the population spread and different language groups. in order to trace the maternal genetic affinity between iranians and other populatio...

background and aims: virus infections represent some of the most important diseases of lily, plants because of the devastating effects caused to the crops and the absence of effective treatments. a survey for virus diseases of lilies, revealed the occurrence of cucumber mosaic virus (cmv) in plants growing in tehran province, iran. materials and methods: during 2013, 50 lily samples with virus-...

background: neosporosis is caused by an obligate intracellular parasitic protozoa neospora caninum which infect variety of hosts. ncsrs2 is an immuno-dominant antigen of n. caninum which is consi-dered as one of the most promising targets for a recombinant or dna vaccine against neosporosis. as no study has been carried out to identify the molecular structure of n. caninum in iran, as first ste...

objective: rna interference (rnai) is the most potent technique for gene silencing in eukaryotic cellular system at transcriptomic level. genetic disorders and cancers are important targets for therapeutic development of this technique. in order to bypass the temporary dpwnregulation by sirna, a new generation of shrna named shrnamir has developed. silencing construct with structure similar to ...

results phylogenetic analysis of the gene revealed that pakistani 1a hcv strains are in the start of third cluster and there is a difference between inter pakistani isolates at primary, secondary and tertiary levels. material and methods patient sera infected with hepatitis c virus, genotype 1a, were obtained from molecular diagnostics lab, cemb, university of the punjab lahore by using bd vacu...

Phytase increases the bioavailability of phytate phosphorus in seed-based animal feeds and reduces the phosphorus pollution of animal waste. Since most animal feeds for pellets are heated up to 65-80 °C, the production of a thermostable structure for phytase can be useful. In this study, we sought to perform bioinformatics analysis of the upstream region and protein structure of fungal phytase ...

introduction: several lines of evidence suggest that the factor xiii (fxiii) 100 g/t polymorphism may influence susceptibility to deep venous thromboembolism (dvt). to explore this hypothesis, we investigated whether this polymorphism is associated with the predisposition to dvt. we also predict the possible impact of residue substitution at codons 34 (val34leu) in a subunits of the fxiii coagu...

This article briefly discusses the complex and intricate mechanisms of functioning signaling systems between plasma membrane nucleus in living organisms. An alternative model DNA packaging is described. The milestone this assumption that winds not around histone octamer: it organized two layers nucleosomes. basic structure chromosomes a triplet A single nucleosome parallelepiped shape (11x11x6 ...

Investigating the Genetic Diversity of BRCA1 Gene in some Domestic and Wild Sheep Breeds World Drawing their Phylogenetic Structure

objective: lentivirus-derived vectors are among the most promising viral vectors for gene therapy which is currently available, but their use in clinical practice is limited due to associated risk of insertional mutagenesis. gene targeting is an ideal method for gene therapy, but it has low efficiency in comparison to viral vector methods. in this study, we are going to design and construct an ...