نتایج جستجو برای: gene transduction
تعداد نتایج: 1186299 فیلتر نتایج به سال:
Targeting viral vectors to certain tissues in vivo has been a major challenge in gene therapy. Cell type-directed vector capsids can be selected from random peptide libraries displayed on viral capsids in vitro but so far this system could not easily be translated to in vivo applications. Using a novel, PCR-based amplification protocol for peptide libraries displayed on adeno-associated virus (...
Adeno-associated viruses are members of the genus dependoviruses of the parvoviridae family. AAV vectors are considered promising vectors for gene therapy and genetic vaccination as they can be easily produced, are highly stable and non-pathogenic. Nevertheless, transduction of cells in vitro and in vivo by AAV in the absence of a helper virus is comparatively inefficient requiring high multipl...
microrna modulation during the in vitro culture of hematopoietic stem cells prior to transplantation
background: human umbilical cord blood (hucb) is an acceptable and readily accessible source of stem cells. there is an ongoing interest in cord blood stem cell therapies; however, little is known about the possible unfavorable effects of laboratory modifications on the isolated hucb cells. the involvement of mirnas in several biological processes has been shown. the aim of this study was to ev...
Lysogeny and transduction describe a type of phage/host interaction and a method of bacterial gene transfer (procaryotic sex), respectively. Although they are often reviewed together, these topics are linked only in that one type of transduction (specialized) has an obligate requirement for a lysogenic interaction. In this chapter we describe the background for understanding both of these proce...
BACKGROUND Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a promising approach to dissect mechanisms of pain in rodents and is a potential therapeutic strategy for the treatment of persistent pain disorders such as neuropathic pain. A number of studies have demonstrated transduction of DRG neurons using herpes simplex virus, adenovirus and more recently, adeno-associat...
Comprendre les mécanismes de positionnement du noyau et l’information relayée par ce dernier constituent des axes recherche importants en Biologie Développement la Reproduction. Chez plupart espèces, position dans l’ovocyte prédéfinit futur embryon. Dans souris, le est centré un gradient pression généré réseau d’actine cytoplasmique nucléé Formine 2. La découverte mécanisme centrage a permis mi...
Vectors based on the adeno-associated virus (AAV) are currently the preferred tools for delivering genes to photoreceptors (PR) in small and large animals. AAVs have been applied successfully in various models of PR dystrophies. However, unknown barriers still limit AAV's efficient application in several forms of severe PR degenerations due to insufficient transgene expression and/or treated ce...
Background: Breast cancer is the most common non- skin cancer among women and it’s the second leading cause of cancer related death in women. Ubiquitin and ubiquitin like proteins are member of signal transduction pathways which have several cellular functions. It has shown that Ubiquitin like protein D (UBD) has accelerated the cancer progress. The aims of this study is evaluation of UBD gene ...
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