Populations of isogenic embryonic stem cells or clonal bacteria often exhibit extensive phenotypic heterogeneity that arises from intrinsic stochastic dynamics of cells. The phenotypic state of a cell can be transmitted epigenetically in cell division, leading to correlations in the states of cells related by descent. The extent of these correlations is determined by the rates of transitions be...

Association, or linkage disequilibrium (LD), mapping is an intensely studied approach to gene mapping (genome-wide or in candidate regions) that is widely hoped to be able to efficiently locate genes influencing both complex and Mendelian traits. The logic underlying association mapping implies that the best possible mapping results would be obtained if the genealogical history of the sampled i...

We introduce a colored coalescent process which recovers random colored genealogical trees. Here a colored genealogical tree has its vertices colored black or white. Moving backward along the colored genealogical tree, the color of vertices may change only when two vertice coalesce. The rule that governs the change of color involves a parameter x. When x = 1/2, the colored coalescent process ca...

PREMISE OF THE STUDY Given that inaccurate taxonomy can have negative consequences for species of conservation concern and result in erroneous conclusions regarding macroecological patterns, efficient methods for resolving taxonomic uncertainty are essential. The primary objective of this study was to assess the evolutionary distinctiveness of the federally endangered plant species Agalinis acu...

Currently, there had been a worldwide growing interest in gene therapy, being the most sustainable therapeutic approach for cancers as well as genetic diseases for upcoming 50 years and beyond.1‒5 Furthermore, several researchers have reported that we can conduct a programmable editing of a target base in genomic DNA without double-stranded DNA cleavage5 and even further to this we can conduct ...

The Spanish government recently announced an official fast-track path to citizenship for any individual who is Jewish and whose ancestors were expelled from Spain during the inquisition-related dislocation of Spanish Jews in 1492. It would seem that this policy targets a small subset of the global Jewish population, that is, restricted to individuals who retain cultural practices associated wit...

Рассматривается вопрос интерпретации персональных гаплотипов современных этнических хакасов применительно к их частным генеалогиям. В ходе ДНК-тестирования Y-хромосомы получены разномаркерные панели гаплотипов, которые были использованы для определения гаплогрупп, а главное – сравнения с персональными устными и архивно-документальными родословными доноров целью верификации родства. Новизна этог...

The acceptance of technology is a crucial factor in successfully deploying technology solutions in healthcare. Our previous research has highlighted the potential of modelling user adoption from a range of environmental, social and physical parameters. This current work aims to build on the notion of predicting technology adoption through a study investigating the usage of a reminding applicati...