Abstract Thousands of exoplanet detections have been made over the last 25 years using Doppler observations, transit photometry, direct imaging, and astrometry. Each these methods is sensitive to different ranges orbital separations planetary radii (or masses). This makes it difficult fully characterize architectures place our solar system in context with wealth discoveries that made. Here, we ...

Abstract BACKGROUND GBM genomic profiling relies on sequencing a limited tumor tissue sample, which is invasive and may underrepresent molecular heterogeneity. CSF, can be obtained less invasively, in intimate contact with lesions better capture the full profile of tumor. However, datasets contemporaneously collected CSF to support this claim have been lacking. To evaluate performance NGS, we c...

Alterations of cellular oncogene expression have been reported in numerous neoplasias, particularly of the hematopoietic system. However, a cause-effect relationship between cellular oncogene abnormalities and oncogenesis is still unclear. In order to explore the involvement of cellular oncogenes in human cancer cells we studied the levels of the expres, . sion of three cellular protooncogenes ...

Restricted types is a method for incorporating the expres-siveness of predicate types in HOL without modifying the HOL type langauge. Restricted types allow predicate restrictions to be placed on the values of HOL constants. Dependant and predicate typing can be approximated using restricted types. The work presented here has been implemented in SML as an extra-logical aid to the development of...