Chemotherapy response in patients with primary breast cancer is difficult to predict and the role of host genetic factors has not been thoroughly investigated. We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence disease progression and treatment response. In this prospective observational stud...

Background: Recent genome-wide association studies demonstrated the between prevalence of chronic kidney disease (CKD) and rs11959928, rs626277, rs7805747 polymorphisms. Materials Methods: In this study, we investigated CKD these polymorphisms in patients controls according to gender. High-resolution melting analysis was performed detect DAB2 DACH1 PRKAG2 single nucleotide Genomic DNA extracted...

Bronchial asthma and juvenile idiopathic arthritis (JIA) are complex genetic diseases. As both represent chronic inflammatory diseases it is likely that they are at least partially influenced by the same genetic variants. One goal in dissecting the genetics of complex diseases is to identify a genetic risk profile. Therefore it is necessary to genotype polymorphisms in many different pathways. ...

INTRODUCTION Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is im...

The objective of this study was to determine allele frequency and genotyping of UGT1A1 polymorphisms (UGT1A1*28 and UGT1A1*6) in Thai colorectal cancer patients who received irinotecan treatment and develop pyrosequencing technique for UGT1A1 genetic polymorphisms detection. The Ninety-one patients entered the study. The results showed the allele frequencies for UGT1A1 genetic polymorphisms wer...

objective(s): asthma results from the interaction between genetic and environmental factors. adam33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. materials and methods: this is a case-control study, where four snps s1 (rs3918396), t1 (rs2280091), t2 (rs2280090), v4 (rs2787094) of adam33 gene have been assessed in patients with allergic asthma and normal cont...

conclusions the obtained results confirm some previous studies regardinga gender specific association of maoa gene with the bipolar disorder. results significant associations were observed regarding maoa-ca (p = 0.016) and maoa-vntr (p = 0.004) polymorphisms in the bipolar females. there was no association between maoa-rflp and bipolar disorder. patients and methods this study is a case-control...

The introduction of molecular markers in genetic analysis has revolutionized medicine. These molecular markers are genetic variations associated with a predisposition to common diseases and individual variations in drug responses. Identification and genotyping a vast number of genetic polymorphisms in large populations are increasingly important for disease gene identification, pharmacogenetics...

BACKGROUND The contribution of the metal components of particulate pollutants to acute respiratory effects has not been adequately evaluated. Moreover, little is known about the effects of genetic polymorphisms of xenobiotic metabolism on pulmonary function. OBJECTIVES This study was conducted to assess lung function decrement associated with metal components in particulate pollutants and gen...

Genetic polymorphisms may affect the susceptibility of individuals or populations to toxic agents that cause developmental defects or disease. This commentary outlines basic concepts of genetic polymorphisms and their relevance to environmentally-induced diseases. First, we provide a basic overview of genetic polymorphisms, with emphasis on single nucleotide polymorphisms (SNPs). Next, we summa...