نتایج جستجو برای: genetic predisposition to disease
تعداد نتایج: 11159105 فیلتر نتایج به سال:
Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide s...
Kikuchi-Fujimoto disease is an idiopathic histiocytic necrotizing lymphadenitis with an autoimmune component triggered by the involvement of CD8 cytotoxic T lymphocyte due to a genetic predisposition. Cases are diagnosed more frequently in female patients, especially in young adults, in all races, more commonly in East Asia, and only isolated in Europe and America. We present the case of a 51-y...
The etiology of oral squamous cell carcinoma (OSCC) is complex and involves many factors. The most clearly defined risk factors are smoking and alcohol, which substantially increase the risk of oral SCC. However, despite this clear association, a substantial proportion of patients develop OSCC without exposure to them, emphasizing the role of other risk factors such as genetic susceptibility an...
OBJECTIVES Numerous studies have shown associations between an on-going depression and elevated serum levels of the acute-phase reactant C-reactive protein (CRP). Also, in suicidal behaviour, a proinflammatory state has been suggested to be of importance for the pathophysiology. There is a genetic susceptibility to suicidal behaviour, but studies with respect to genes related to inflammation ar...
A recent study demonstrated that a particular genetic susceptibility (LOC387715), combined with smoking, confers a significantly higher risk of AMD than either factor alone (Schmidt et al 2006). This is consistent with reports from family aggregation studies, which suggest that a first-degree relative of an individual with AMD is five times more likely to develop AMD than a family member of som...
The prevalences of asthma and atopy were examined in the families of 77 asthmatic and 87 control children attending a London general practice. The prevalence of asthma in first degree relatives of asthmatic children was found to be significantly higher than in relatives of control children, and this difference was more pronounced for relatives of atopic probands than for relatives of non-atopic...
ence lung cancer (e.g., diet, exercise, genetic predispositions). Regarding our own meta-analysis, Block and Crain (2007) stated that we “did not provide references for the studies included in their meta-analysis; therefore it is impossible to replicate their study or determine if they again used the faulty transformation to convert odds ratios and relative risk to correlation coefficients” (p....
This article discusses the desirability of legislation focusing on genetic discrimination, in particular in the context of insurance. Many American states and some European countries as well as the Council of Europe have introduced protective measures against discrimination on the basis of genetic susceptibility. The author questions their effectiveness and queries whether they may be inequitab...
Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first-deg...
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