Eighteen polymorphic microsatellite markers suitable for population genetic studies and protein kinase encoding genic variation measurement were developed for rice blast fungus Magnaporthe grisea. Polymorphism was evaluated by using 46 isolates collected from diverse geographical locations and rice varieties. Preliminary results indicate that each locus harbors two to

In this issue of Cancer Cell, Yang et al. describe a causal relationship between gene body methylation and gene expression and a role for genic methylation in response to clinical DNA methylation inhibitors, which suggests that the mechanism of action of these inhibitors includes gene body hypomethylation-induced downregulation of cancer-associated genes.

prognosis. Physicians generally considered CFA to be a clinical diagnosis and Background – Mortality due to cryptodid not initiate treatment in up to half of genic fibrosing alveolitis (CFA) is inpatients at presentation. creasing, particularly in the elderly. (Thorax 1997;52:38–44) Optimum management remains uncertain and previous studies of the disease have

This is a report of a nine-year-old boy with both mitral stenosis and regurgitation and extensive endomyocardial fibrosis of the left ventricle. Focus is given to the singularity of the fibrotic process, with an emphasis on the etiopatho-genic aspects.

Currently, much effort is invested in the development and optimization of in vitro systems for toxicity testing (Godoy et al. However, one major problem in this field of research is the difficulty to link observations made in vitro to adverse effects in vivo (Ghallab, 2013; Bolt, 2013). To come closer to a solution of this fundamental problem , Waldmann et al. (2014) performed a study in which ...

BACKGROUND Asian lotus (Nelumbo nucifera Gaertn.) is the national flower of India, Vietnam, and one of the top ten traditional Chinese flowers. Although lotus is highly valued for its ornamental, economic and cultural uses, genomic information, particularly the expressed sequence based (genic) markers is limited. High-throughput transcriptome sequencing provides large amounts of transcriptome d...

Eukaryotic genomes are mostly composed of noncoding DNA whose role is still poorly understood. Studies in several organisms have shown correlations between the length of the intergenic and genic sequences of a gene and the expression of its corresponding mRNA transcript. Some studies have found a positive relationship between intergenic sequence length and expression diversity between tissues, ...