A 14-day subchronic genotoxicity of Nimesulide was evaluated by employing mouse bone marrow chromosomal aberration test. The Nimesulide administered orally for 2 weeks at the rate of 1.5, 2.5, 5 mg/kg body weight in swiss albino mice. The results show decreased mitotic activity in all groups of Nimesulide treatments. Similar results concerning the chromosomal aberrations revealed in all treated...

normal 0 false false false en-us x-none ar-sa background: more than 100,000 iranian veterans and civilians still suffer from various long-term complications due to their exposure to sulfur mustard (sm) during the iran–iraq war in 1983–88. the aim of the study was to investigate dna damage of sm in veterans who were exposed to sm, 23–27 years prior to this study. materials and methods: blood sam...

background: the present study was undertaken to study the larvicidal activity of different extracts of nerium ole- ander leaves, and post-treatment temperature- toxicity relationship of these extracts against culex pipiens. further, the most potent extract was used to evaluate its biological and genotoxic activities. methods: crude extracts of n. oleander leaves were prepared using water, chlor...

In vitro genotoxicity assays are often used to compare tobacco smoke particulate matter (PM) from different cigarettes. The quantitative aspect of the comparisons requires appropriate statistical methods and replication levels, to support the interpretation in terms of power and significance. This paper recommends a uniform statistical analysis for the Ames test, mouse lymphoma mammalian cell m...

Genotoxic effects of EMS have been assessed in fish, A. testudineus, using widely accepted cytogenetic protocols like chromosome aberrations, nuclear anomalies in red blood cells and abnormal sperm head morphology. In addition, gel electrophoretic protein profiles and total protein contents in nine selected tissues were analysed for evaluating their utility as potential indicators of genotoxici...

At the request of the European Food Safety Authority, the Scientific Committee has reviewed the 8 current state-of-the-science on genotoxicity testing strategies and provided a commentary and 9 recommendations on testing strategies, bearing in mind the needs of EFSA’s various Scientific Panels 10 to have appropriate data for risk assessment. It is hoped that this opinion will contribute to grea...

Chemical components of the acetone and watery extract of Ambrosia artemisiifolia (LINNAEUS, 1753) plant, and the two identified lactones in the acetone extract: the ambrosin and dihydroambrosin, was tested for genotoxicity activities. The genotoxicity of the extract was tested on the eukaryotic model system Drosophila melanogaster using the sex-linked recessive lethal test (SLRL test). The resu...

The protective effect of garlic extract in chromium induced genotoxicity was evaluated using analysis of chromosomal aberrations in somatic cells of mice in in vivo animal model. Three doses of garlic extracts were selected for modulation and administered to animals after priming with chromium all the animals were killed after 24 hrs of treatment and the mitotic preparations were made. A signif...

Mammalian cells incur DNA damage and alterations as a result of internal factors, such as stress, environment, oxidation and metabolism, as well as exposure to external stimuli, such as chemical compounds, UV and cosmic radiation. Genotoxicity studies aim to identify and understand the mechanisms of DNA damage and repair, and also to seek methods of pathway regulation and dysregulation for impr...

The aim of this study was to compare the effects of cationic micelle and liposome drug delivery systems on liver and lung cells in a toxicological in vitro screening model, with observations on cytotoxicity and genotoxicity. A screening battery was established for assessment of a broad range of parameters related to adverse effects. Clear concentration response effects were observed related to ...