BACKGROUND Glucose is a more efficient substrate for ATP production than free fatty acid (FFA). Insulin resistance (IR) results in higher FFA concentrations and impaired myocardial glucose use, potentially worsening ischemia. We hypothesized that metabolic manipulation with a hyperinsulinemic euglycemic clamp (HEC) would affect a greater improvement in left ventricular (LV) performance during d...

We describe a quantitative assay of transendothelial migration (TEM) that allows us to selectively study the interaction of monocytes with confluent human endothelial cell (HEC) monolayers. The HEC are grown on hydrated collagen gels; the monocytes need not be purified. 100% of monocytes transmigrated the monolayer within 1 h at 37 degrees C and accumulated in the subendothelial collagen; TEM o...

BACKGROUND Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) coactivates multiple transcription factors and regulates several metabolic processes. In this study, we focused on the roles of PGC-1α in the apoptosis of endometrial cancer HEC-1A cells. MATERIALS AND METHODS PGC-1a expression in the HEC-1A cells was detected with real-time polymerase chain reaction and ...

We describe a quantitative assay of transendothelial migration (TEM) that allows us to selectively study the interaction of monocytes with confluent human endothelial cell (HEC) monolayers. The HEC are grown on hydrated collagen gels; the monocytes need not be purified. 100% of monocytes transmigrated the monolayer within 1 h at 37~ and accumulated in the subendothelial collagen; TEM oflymphocy...

In this paper, we propose the HEC-PF scheme, an enhancement of our previous H-EC scheme for effective data forwarding in opportunistic networks. The enhanced scheme modifies the aggressive forwarding phase of the H-EC scheme by implementing a new Probabilistic Forwarding feature, which decides whether to forward a message to a newly encountered node based on the delivery probability. Using simu...

An attempt was made to formulate Buccal patches of Isoxsuprine hydrochloride, a potent and long acting vasodilator and uterine suppressant , by using Hydroxyl propyl methyl cellulose(HPMC), Polyvinyl pyrolidone K-30 (PVP K-30) and Hydroxyl ethyl cellulose (HEC). Twelve batches of buccal patches were prepared by solvent casting technique in which the best formulation was found out. The polymers ...

Identification of novel factors critical for epithelial to mesenchymal transition (EMT) and cancer initiating cell (CIC) formation may aid in the identification of novel therapeutics for the treatment of endometrial cancer. The present study demonstrated that L1 cell adhesion molecule (CAM) is critical for EMT and formation of CICs in endometrial cancer. Overexpression of L1CAM may promote EMT ...

The asynchronous transfer mode (ATM) is a promising technique for broadband switching that is capable of supporting high-bit-rate multimedia services. Progress in all-optical parallel processing shows that photonics may be used in the future in full-functionality ATM switching nodes. All-optical switching fabrics and buffers have already been demonstrated. Fewer studies have been dedicated to A...

Chemotherapy-induced nausea and vomiting (CINV) is a serious adverse effect of chemotherapy that limits patients' physical, mental, and functional capabilities and may cause a delay or cessation of treatment. Antiemetic therapy can reduce the incidence of CINV. Research, using data from visits by patients receiving moderately (MEC) or highly emetogenic chemotherapy (HEC), identified that antiem...

The aim of the present study was to investigate the effects of the mammalian target of rapamycin (mTOR) inhibitor, RAD001, on the growth of human endometrial cancer cells. The effects of RAD001 on human endometrial cancer Ishikawa and HEC-1A cell proliferation were determined by MTT assay. Green fluorescent protein microtubule-associated protein 1 light chain 3α (GFP-LC3) protein aggregates wer...