AIMS To assess the expression of Id proteins in trophoblastic tissues and to correlate this with clinical parameters, proliferative and apoptotic indices as well as to related oncogene expression. METHODS AND RESULTS Immunohistochemistry for Id1, Id2, Id3 and Id4 was performed on 83 trophoblastic tissues including 17 normal first-trimester placentas, seven term placentas, 47 hydatidiform mole...

Background. Gestational choriocarcinoma (GC) is a recognized clinicopathological subtype of gestational trophoblastic neoplasia that usually metastasizes hematogenously to highly vascular organs like the lung, liver, and brain. However, orbital metastasis to the choroid and lacrimal gland is a rare occurrence. Case Presentation. A 21-year-old female presented with headache and left orbital swel...

Background: Choriocarcinoma is a rare, aggressive subtype of gestational trophoblastic neoplasia. The diagnosis of metastatic choriocarcinoma in the setting of a viable intrauterine pregnancy is exceedingly rare and often associated with feto-maternal hemorrhage. Case: An otherwise healthy Gravida 1 Para 0 at 34 weeks gestational age presented with metastatic choriocarcinoma and a viable fetus....

Background—The p21 gene mediates growth arrest by inhibiting G1 cyclin dependent kinases and has been considered as a downstream eVector of the tumour suppressor gene p53. Aim—To analyse the role of p21 in gestational trophoblastic disease. Methods—The immunohistochemical expression of p21 gene was measured in 33 placentas, 28 partial hydatidiform moles, 54 complete hydatidiform moles, and 13 c...

estational trophoblastic disease includes following forms of growth disturbance of the human trophoblast: hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumors. Term gestational trophoblastic disease is applied to the letter three conditions. Diagnosis and decision to institute treatment are sometimes undertaken without histopathological finding. Gestational tr...

Objective The objective of this study was to evaluate the characteristics and outcomes patients treated for gestational trophoblastic neoplasia (GTN) with second-line 5-day dactinomycin after failed first-line 8-day methotrexate. Methods From 1999 2017, methotrexate resistant GTN second line were identified at French Trophoblastic Disease Reference Center. Using univariate mul...