Articular cartilage defects are considered a major health problem because articular cartilage has a limited capacity for self-regeneration (1). Untreated cartilage lesions lead to ongoing pain, negatively affect the quality of life and predispose for osteoarthritis. During the last decades, several surgical techniques have been developed to treat such lesions. However, until now it was not poss...

0184 Preparing for Death How does one prepare for death? Those who have created a public persona must add to any spiritual ponderings about eternity the mundane chore of organizing their literary archives to protect any of life’s secrets that seem worth the effort. That task involves choosing what diaries, letters, drafts, and laundry lists to donate to a university or to leave in a closet for ...

Clock (CLK), is replaced by an analogous protein, D-80336 Munich NPAS2 (also called MOP4). Like CLK, it heterodimerizes Germany with BMAL1 (also called MOP3) to drive transcription of a collection of downstream effectors, including mper1, mper2, and mcry1. Further experiments demonstrate Andre Gide wrote: " If I were not there to make them that, like in the feedback loop where CLK and BMAL1 acq...

Background V-domain Ig Suppressor of T cell Activation (VISTA) is an immune-suppressive checkpoint inhibitor response. VISTA expressed in the immuno-suppressive tumor microenvironment, mostly by cells myeloid lineage, and its blockade can restore efficient antitumor immune response especially hard-to-treat tumors. 1 In addition, increase expression has been described after treatment current inh...

BACKGROUND Treatment of osteochondritis dissecans (OCD) of the knee is challenging, and evidence for stage-dependent treatment options is lacking. Basic science approaches utilizing animal models have provided insight into the etiology of OCD but have yet to produce a reliable and reproducible large animal model of the disease on which to test new surgical strategies. PURPOSE/HYPOTHESES The p...

VOLUME 115 | NUMBER 2 | February 2007 • Environmental Health Perspectives As scientists, communication—not only with those outside our area of expertise but also with those within our scientific sphere—is an important responsibility, though often an ongoing challenge. As NIEHS director, I increasingly realize that, as the writer André Gide said, “The most important things to say are those which...