OBJECTIVES The population health approach is increasingly recognized for its role in health system reform; however, its broad scope and definition have been criticized for being a barrier to clear communication. This qualitative study examined the way senior healthcare leaders in Canada conceptualize and operationalize the population health approach in planning and decision-making. FINDINGS C...

Among 1739 male survivors of myocardial infarction, mortality over 5 years was examined in relation to presence of complex ventricular premature complexes (R on T, runs of two or more, multiform or bigeminal complexes) identified during 1 hour of monitoring. Such arrhythmia was associated with excess risk of death over the entire period. Men with R on T or runs during the hour show a 5-year sud...

Convincing epidemiological data suggest an inverse association between cancer and neurodegeneration, including Alzheimer's disease (AD). Since both AD and cancer are characterized by abnormal, but opposing cellular behavior, i.e., increased cell death in AD while excessive cell growth occurs in cancer, this motivates us to initiate the study into unraveling the shared genes and cell signaling p...

Diabetic angiopathy is a generalised systemic disease of the vascular system which afflicts both distribution vessels (diabetic macroangiopathy) and microcirculation (diabetic microangiopathy). The diabetic angiopathy, as well as other angiostenotic diseases (obliterations, obstructions, occlusions) result in one common consequence--ischaemia. This study is based on an analysis of a large group...

Malignant glioblastoma multiform (GBM, WHO grade IV) are the most malignant and prevalent intracranial tumor providing for well over one half of all gliomas (Hoffman et al., 2006; Schneider et al., 2010). GBM is characterized by a rapid growth and short time to progression in most treated patients. Current therapeutic modalities include surgical resection, radio-surgical or external irradiation...

We present and describe the NEsted SeTs for Object hieRarchies (NESTOR) Framework that allows us to model, manage, access and exchange hierarchically structured resources. We envision this framework in the context of Digital Libraries and using it as a mean to address the complex and multiform concept of interoperability when dealing with hierarchical structures. The NESTOR Framework is based o...

Biomedical imaging based on different physical principles has played a more and more important role in medical diagnosis. Multiform methods of image diagnosis provide doctors and clinicians with various anatomical and functional information to carry out exact diagnosis and effective treatment. Image registration is the process of combination the different sets of data of the same object, which ...

Liquid chromatography-tandem mass spectrometry was used to analyze plasma proteins of volunteers (control) and patients with glioblastoma multiform (GBM). A database search was pre-set with a variable post-translational modification (PTM): phosphorylation, acetylation or ubiquitination. There were no significant differences between the control and the GBM groups regarding the number of protein ...

Pattern Recognition defined as a classification of input data via extraction important features from a lot of noisy data. The identification or interpretation of the pattern in an image can be described effectively with the help of Pattern Recognition (PR). It aims to extract information about the image to classify its contents. Inputs are in the form of digitized binary valued 2D images or tex...

Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare and fatal disease with no special clinical manifestations. Here, we report the dynamic brain magnetic resonance imaging (MRI) changes in a 30-year-old female PDLG patient over a 10-month period. MRI showed aggressive dilation of the subarachnoid space and the ventricular system, numerous encapsulated cysts in the subarachnoid space and...