BACKGROUND Calmodulin-dependent cyclic nucleotide phosphodiesterase (CaMPDE) has been extensively studied and characterized in normal mammalian tissues; however very little is known about this enzyme in human brain tumors. It has been established that high levels of this enzyme exist in non-central nervous system tumors, PDE inhibitors or cAMP analogues have been used to treat them. This study ...

Understanding the mechanisms of glioblastoma at the molecular and structural level is not only interesting for basic science but also valuable for biotechnological application, such as the clinical treatment. In the present study, bioinformatics analysis was performed to reveal and identify the key genes of glioblastoma multiforme (GBM). The results obtained in the present study signified the i...

Primary spinal cord glioblastoma multiforme(GBM) is a rare clinical entity with an aggressive course andan invariably dismal prognosis. There are around 200 reportedcases of GBM in total and approximately 70 casesin the cervical region. Median survival for this disorder only12 months. We report case 36 year old female patientwith primary GBM.

BACKGROUND Malignant cell clones resistant to chemotherapy and radiotherapy frequently lead to treatment failure in patients with glioblastoma multiforme. Preliminary studies suggest that adding chloroquine to conventional therapy may improve treatment outcomes. OBJECTIVE To examine the effect of adding chloroquine to conventional therapy for glioblastoma multiforme. DESIGN Randomized, doub...