Abstract Funding Acknowledgements Type of funding sources: None. Background Primary intervention in acute coronary syndrome (ACS) is often followed by the second-stage procedure when other atherosclerotic lesions are present. However, there no data regarding early effects such a strategy on left ventricular function. Speckle-tracking echocardiography has been proven sensitive method assessing m...

Cancer cells reprogram metabolism to provide the energy, nucleotides, lipids, amino acids and other building blocks required to proliferate and survive in the stressful tumor microenvironment [1]. Changes in cancer metabolism were first noted in the 1920’s with Otto Warburg’s discovery that tumors show increased aerobic conversion of glucose to lactate (termed the Warburg Effect). A recent revi...

BACKGROUND Different aspects of acute stroke management and strategies for stroke prevention derive from two viewpoints: specific traditional and historical backgrounds and evidence-based medicine from modern randomized controlled trials (RCTs), meta-analysis and authorized clinical practice guidelines (GLs). Regarding stroke, GLs have been published by national and international organizations ...

Parallel GMRES algorithms for solution of convective transport problems on distributed memory computers are investigated in this paper. The space-time FEM stabilised by the GLS formulation is applied as the most accurate and stable. The parallel algorithms based on the domain decomposition and iterative GMRES solver are implemented in order to reduce long computing time associated with space-ti...

BACKGROUND AND OBJECTIVES The development of postoperative left ventricular (LV) dysfunction is a frequent complication in patients with chronic severe mitral valve regurgitation (MR) and portends a poor prognosis. Assessment of myocardial deformation enables myocardial contractility to be accurately estimated. The aim of the present study was to evaluate the predictive value of preoperative re...

Contractile function is considered to be precisely measurable only by invasive hemodynamics. We aimed to correlate strain values measured by speckle-tracking echocardiography (STE) with sensitive contractility parameters of pressure-volume (P-V) analysis in a rat model of exercise-induced left ventricular (LV) hypertrophy. LV hypertrophy was induced in rats by swim training and was compared wit...

BACKGROUND In obstructive hypertrophic cardiomyopathy patients with preserved left ventricular (LV) ejection fraction, we sought to determine whether LV global longitudinal strain (LV-GLS) provided incremental prognostic utility. METHODS AND RESULTS We studied 1019 patients with documented hypertrophic cardiomyopathy (mean age, 50±12 years; 63% men) evaluated at our center between 2001 and 20...

The desire to predict who will develop heart failure (HF) has inspired researchers for a long time. Numerous so-called predictive biomarkers have been developed, studied, published, and forgotten. Various suggestions of biomarkers have been deemed to add little to clinical practice.1–3 However, a few have reached current clinical practice, including NT-proBNP, troponins, and creatinine, which c...

Background: BCS class II and IV drugs, which have low solubility, provide a number of challenges for formulation scientists working on oral delivery of drugs. Aims: The aim and purpose of the present work was to design a gel liquisolid tablets for Atorvastatin calcium a water insoluble drug to increase its dissolution rate there by its bioavailability. Materials and Methods: The preformulation ...