We have already described the course of skin ulcers due to this parasite after intralesional Glucantime1. Because there appeared to be a slight response over 30 days we have extended our observations to the use of two topical preparations of Pentostam. These are the solution of Pentostam (Wellcome) inoculated intralesionally and Pentostam powder mixed with Aquaphor in the form of a cream. Once ...

BACKGROUND The present study aimed to evaluate the effect of methotrexate (MTX) alone and in combination with meglumine antimoniate (MA, Glucantime) against sensitive and MA-resistant Leishmania tropica stages in vitro. METHODS The present study was carried out in 2014 in Leishmaniasis Research Center at School of Medicine, Kerman University of Medical sciences, Kerman, Iran. The effects of M...

The aim of the present work was to evaluate antileishmanial activity of Astronium fraxinifolium and Plectranthus amboinicus. For the in vitro tests, essential oil of P. amboinicus (OEPA) and ethanolic extracts from A. fraxinifolium (EEAF) were incubated with 10(6) promastigotes of L. (Viannia) braziliensis. The OEPA was able to reduce the parasite growth after 48 h; nonetheless, all the EEAFs c...

The production of ergosterol lipid involves the activity different enzymes and is a crucial event for Leishmania membrane homeostasis. Such can be blocked by azoles allylamines drugs, such as antifungal butenafine chloride. This drug was active on parasites that cause cutaneous visceral leishmaniasis. Based leishmanicidal chloride considering absence reports about therapeutic potential this in ...

background & aim: cutaneous infection caused by protozoa the genus leishmania are a major worldwide health problem, with high endemicity in developing countries including middle east, africa and latin america. in the absence of a vaccine, there is an urgent need for effective drugs to replace and supplement those in current use. experimental: in this study, the in vivo efficacy of artemisia...

BACKGROUND Cutaneous leishmaniasis (CL) is an endemic disease in developing countries. Although pentamidine orantimonite (Glucantime) has been recommended for cutaneous leishmaniasis treatment by the World Health Organization, there are some concerns too such as high cost, side effects, need for frequent injections, and restricted efficacy. Therefore, different methods have been used for CL tre...

Background: Cutaneous leishmaniasis (CL) remains a major health threatening disease in Iran and many countries around the world. Antimony compounds are currently used to treat CL. Due side effects high resistance, use of alternative therapies, especially nanoparticles, has been considered by researchers. The aim this study was investigate anti-leishmanial activity selenium nanoparticles (SeNPs)...