Glucosamine is a natural drug widely used for treating osteoarthritis and usually left until it expires, which will cause waste of resources if treated as garbage. However, its molecule contains many heteroatoms, entitling to be potential corrosion inhibitor. In this investigation, the inhibition activities two types expired glucosamine drugs (glucosamine hydrochloride sulfate) on carbon steel ...

Sustained hyperglycemia can cause peripheral insulin resistance and pancreatic beta-cell dysfunction and has been termed glucose toxicity or glucose-induced desensitization. Glucosamine, a product of glucose flux through the hexosamine biosynthetic pathway (HBP), causes insulin resistance in peripheral tissues and has been shown to cause abnormal glucose-insulin secretion coupling, and thus has...

Recent studies in this laboratory, concerned with hexosamine metabolism, required Gm-6-P,’ Galm-BP, and their respective N-acetyl derivatives. Several methods are available for the preparation of Cm-6-P, but there appears to be no previous report of Calm-6-P, although an acid-stable Galm-P has been isolated from cartilage (4). Earlier reports indicated that hexokinase and ATP would phosphorylat...

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) first line for the medium to long term management of OA, due to their ability to control pain, improve function, and delay joint structural changes. Among SYSADOAs, glucosamine is...

BACKGROUND With increasing use of glucosamine-containing supplements for the treatment of osteoarthritis, there is increasing concern in the medical community about possible toxic effects. The present study was undertaken to determine whether glucosamine supplementation altered hemoglobin A1c concentrations in patients with well-controlled diabetes mellitus. OBJECTIVE To evaluate possible eff...

Short-chain fatty acid (SCFA)-carbohydrate hybrid molecules that target both histone deacetylation and glycosylation pathways to achieve sugar-dependent activity against cancer cells are described in this article. Specifically, n-butyrate esters of N-acetyl-D-mannosamine (But4ManNAc, 1) induced apoptosis, whereas corresponding N-acetyl-D-glucosamine (But4GlcNAc, 2), D-mannose (But5Man, 3), or g...

Incubation of UDP-N-acetyl[3H]glucosamine with purified inner membrane preparations of a mutant (UDPgalactose-4-epimeraseless and glucosamine-6-phosphate synthetaseless) Escherichiu coli 0111-B4 results in the incorporation of N-acetyl[3H]glucosamine into two components, A and B, that may be distinguished by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. A contain...