I N A PREVIOUS STUDY of the effect of thyroidectomy on oral glucose tolerance, interpretation of the findings was complicated by the marked difference in size between thyroidectomized and normal control rats (I). It was demonstrated that age had a pronounced effect on the rate of intestinal absorption of glucose, but it was not ascertained if this was a direct effect of age or secondary to its ...

The Hertfordshire Cohort Study based in the U.K. was the first to report associations between fetal or infant growth and the prevalence of adult glucose intolerance and diabetes. Many studies have replicated the findings with respect to birth weight, but there have been fewer observations in relationship to infant growth, because this is infrequently recorded in routine datasets. Recently, we c...

BACKGROUND The best strategy to identify women with gestational diabetes mellitus (GDM) is unclear. OBJECTIVES To perform a systematic review to calculate summary estimates of the sensitivity and specificity of the 50-g glucose challenge test for GDM. SEARCH STRATEGY Systematic search of MEDLINE, EMBASE and Web of Science. SELECTION CRITERIA Articles that compared the 50-g glucose challen...

BACKGROUND Modeling studies of the insulin-glucose relationship have mainly utilized parametric models, most notably the minimal model (MM) of glucose disappearance. This article presents results from the comparative analysis of the parametric MM and a nonparametric Laguerre based Volterra Model (LVM) applied to the analysis of insulin modified (IM) intravenous glucose tolerance test (IVGTT) da...

In this report a new approach is introduced that allows estimation of insulin sensitivity (S(I)) from orally ingested glucose during an oral glucose tolerance test (OGTT) or a meal glucose tolerance test (MGTT) in normal subjects. The method hinges on the classic minimal model of glucose kinetics that is coupled with an equation describing the rate of appearance of glucose into the circulation ...

OBJECTIVE The study objective was to assess the relationship between β-cell function and HbA(1c). RESEARCH DESIGN AND METHODS A total of 522 Mexican American subjects participated in this study. Each subject received a 75-g oral glucose tolerance test (OGTT) after a 10- to 12-h overnight fast. Insulin sensitivity was assessed with the Matsuda index. Insulin secretory rate was quantitated from...

OBJECTIVE—Left ventricular hypertrophy (LVH), an independent risk factor for cardiovascular (CV) morbidity and mortality, recognizes a multifactorial pathogenesis. A plasma glucose value $155 mg/dL for the 1-h postload plasma glucose during an oral glucose tolerance test (OGTT) identifies subjects with normal glucose tolerance (NGT) at high risk for type 2 diabetes. We addressed the question if...

BACKGROUND Controversy surrounds the decision to adopt the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria for the diagnosis of gestational diabetes mellitus (GDM) as fears that disease prevalence rates will soar have been raised. AIMS To investigate the prevalence of pregnancy complicated with GDM before and after the introduction of the IADPSG 2010 diagnos...

In this paper we try to define insulin resistance (IR) precisely for a group of Chinese women. Our definition deliberately does not depend upon body mass index (BMI) or age, although in other studies, with particular random effects models quite different from models used here, BMI accounts for a large part of the variability in IR. We accomplish our goal through application of Gauss mixture vec...