Abstract Purpose The therapeutic use of oral hypoglycaemic agents in the management type-2 diabetes mellitus (T2DM) is without adverse effects; thus, calls for alternative and novel candidates from natural products medicinal plants. Method study explored molecular docking dynamics (MD) simulation approaches to identify key antidiabetic metabolites Crescentia cujete . Results Molecular results i...

OBJECTIVE Clinical trials provide information regarding the safety and efficacy of medications used to manage type 2 diabetes but do not elucidate drug effectiveness in a typical managed care environment. The aim of this study was to characterize "real-world" drug utilization patterns from both a prescriber and a patient perspective. RESEARCH DESIGN AND METHODS We conducted a retrospective an...

BACKGROUND Panama has an extensive mangrove area and it is one of the countries with the highest biodiversity in America. Mangroves are widely used in traditional medicine, nevertheless, there are very few studies that validates their medicinal properties in America. Given the urgent need for therapeutic options to treat several diseases of public health importance, mangrove ecosystem could be ...

Several treatments for DM are available. These include oral hypoglycaemic agents (sulfonylureas, glitinides, metformin, glitazones, α-glucosidase inhibitors), incretin enhancers and mimetics, and insulin. Available insulin preparations include very short-, short-, intermediateand long-acting agents. While all diabetic treatments aim to reduce blood glucose levels they have a diverse range of me...

INTRODUCTION Pneumatosis cystoides intestinalis is characterized by the presence of multiple gas-filled cysts in the intestinal wall, the submucosa and/or subserosa of the intestine. The term pneumatosis cystoides coli is synonymous with pneumatosis cystoides intestinalis when the disorder is limited to the colon. It is a secondary finding caused by a wide variety of underlying gastrointestinal...

Thioenethiophene derivatives represent an important class of compounds with diverse biological activities. We describe here the synthesis of a new series of thieno[2,3-b]thiophene containing bis-heterocyclic compounds 3-7. All the compounds were evaluated for their in vitro antioxidant potential, α-glucosidase and β-glucuronidase inhibiton and anticancer activity against PC-3 cell lines. Compou...