Antioxidant nutrients have demonstrated potential in protecting against exercise-induced oxidative stress. alpha-Lipoic acid (LA) is a proglutathione dietary supplement that is known to strengthen the antioxidant network. We studied the effect of intragastric LA supplementation (150 mg/kg, 8 wk) on tissue LA levels, glutathione metabolism, and lipid peroxidation in rats at rest and after exhaus...

Glutathione transferases (GSTs) are dimeric enzymes containing one active-site per monomer. The omega-class GSTs (hGSTO1-1 and hGSTO2-2 in humans) are homodimeric and carry out a range of reactions including the glutathione-dependant reduction of a range of compounds and the reduction of S-(phenacyl)glutathiones to acetophenones. Both types of reaction result in the formation of a mixed-disulfi...

The abilities of two types of chitosan oligosaccharides, chitosan oligosaccharide I (1-kDa<MW<3-kDa) and chitosan oligosaccharide II (3-kDa<MW<5-kDa), to prevent 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress were examined in ICR mice. Chitosan oligosaccharide I had no effect on TCDD-induced alterations in lipid peroxidation and glutathione S-transferase activity or liver w...

background: hyperthyroidism is associated with liver oxidative stress causing liver dysfunction in many hyperthyroid patients. the hepatoprotective effect of satureja khuzestanica essential oil (skeo), as herbal origin antioxidant and anti-inflammatory agent on the hyperthyroidism induced hepatotoxicity and oxidative stress is investigated. methods: adult male sprague dawley rats were divided i...

glutathione s-transferases (gsts) are a major family of detoxification enzymes which possess a wide range of substrate specificities. interest in insect gsts has primarily focused on their role in insecticide resistance. in this study, following world health organization (who) routine susceptibility test, dna was extracted from specimens of anopheles stephensi collected from the kazeroon distri...

the aim of this study was to detect the glutathione s-transferase(gst) enzyme activity of healthy / cystic liver as a diagnostic biomarker for hydatidosis. in order to compare with liver tissue, the level of the gsts enzyme activity of parasite was also determined.parasites were collected from sheep liver tissue with hydatid cysts at a local abattoir and washed with pbs buffer. collected parasi...