One useful methodology that has been used to give insight into how chemically synthesized inhibitors bind to enzymes and the reasons underlying their potency is crystallographic studies of inhibitor-enzyme complexes. Presented here is the X-ray structural analysis of a representative family 20 exo-β-N-acetylhexosaminidase in complex with various known classes of inhibitor of these types of enzy...

Borreria vertcillata is a woody perennial shrub with false-button weedy herb belonging to the family (Rubiaceae), used for treating/curing various forms of diseases across world since ancient times. Qualitative phytochemical screening pulverized whole plant was carried out using four different solvent extracts (N-hexane, chloroform, ethyl-acetate and methanol). The phytochemicals screeened cont...

The bushhopper Phymateus leprosus (Fabricius) in the field shows a special appetite for the milkweed Asclepias fruticosa. Asclepiadaceae, like Apocynaceae and Scrophulariaceae, contain cardiac glycosides. Raw and purified extracts of these plants phagostimulate larval and adult P. leprosus. We also screened natural and half-synthetic compounds found in those plant extracts. While saponins and s...

Ziziphus mauritiana Lam. is an important medicinal plant belonging to the family Rhamnaceae. Preliminary phytochemical screening of the leaf extract of Ziziphus mauritiana revealed presence of different types of secondary metabolites such as glycosides, tannins, phenols and saponins. The methanol leaf extracts of Ziziphus mauritiana showed significant activity against Staphylococcus aureusand E...

Three cardiac glycosides were screened for pharmacological effects on isolated rat jejunum. The contraction of rat jejunum with epoxyscillirosidin, a non-cumulative bufadienolide, and cotyledoside and tyledoside D, both cumulative neurotoxic bufadienolides were compared with methacholine. The results indicate that all three bufadienolides cause contraction of jejunal smooth muscle. When combine...

Forsythosides H-J (1-3), three new caffeoyl phenylethanoid glycosides (CPGs), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl., together with six known phenylethanoid glycosides: Forsythoside A (4), Forsythoside F (5), Forsythoside E (6), 2-(3,4-dihydroxyphenyl)ethyl-beta-D-glucopyranoside (7), phenethyl alcohol beta-D-xylo-pyranosyl-(1-->6)-beta-D-glucopyranoside (8) and calc...

The Effect of Calcium and Sodium Ion on the Frequency-Force Relationship in Cardiac Muscle. DAVID 0. TEIGER AND ALFRED FARAH 1 The Uptake and Binding of Six Radiolabeled Cardiac Glycosides by Guinea-Pig Hearts and by Isolated Sarcoplasmic Reticulum. S. DUTTA, S. Gosw u, D. K. DATrA, J. 0. LINDOWER AND B. H. MARKS 10 The Effects of Cardiac Glycosides and Their Interaction with Catecholamines on ...