Objective-To study the effectiveness of single-dose perfloxacin and ciprofloxacin in the treatment of uncomplicated gonococcal urethritis in males. Setting-Department of STD Control, Kelantan Road, Singapore. Method-160 male patients with uncomplicated gonococcal urethritis were assigned alternately to receive single oral doses of either perfloxacin 800 mg or ciprofloxacin 250 mg. Results-Of th...

In humans, gonococcal infection occurs in environments limited with respect to free iron. Neisseria gonorrhoeae produces increased quantities of iron-regulated membrane proteins when grown under in vitro conditions which restrict the availability of free iron. Using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot (immunoblot) techniques, we studied the reactivity of s...

Background: Both gonorrhoea and chlamydia urethritis present with dysuria and discharge. It is difficult to differentiate by history and clinical examination alone. Empirical treatment may induce drug resistance whereas complications and the spread of infections may be increased if treatment is started only after the availability of gonococcal culture and chlamydia polymerase chain reaction (PC...

It is uncertain which methods for the diagnosis of rectal gonococcal and chlamydial infection are optimal. This study evaluated the performance of culture and nucleic acid amplification tests (NAATs) for rectal chlamydial and gonococcal diagnosis. From July 2003 until February 2007, 441 rectal test sets were collected from individuals attending a sexually transmitted disease clinic and three HI...

Neisseria gonorrhoeae isolated from patients with disseminated infection are often of the porin (Por1A) serotype and resist killing by nonimmune normal human serum. The molecular basis of this resistance (termed stable serum resistance) in these strains has not been fully defined but is not related to sialylation of lipooligosaccharide. Here we demonstrate that Por1A bearing gonococcal strains ...

With the objective of determining if specific sexually transmitted diseases (STDs) are associated with prematurity (birth weight less than or equal to 2500 g and gestational age less than or equal to 36 weeks), a case-control study was conducted to evaluate women for serologic evidence of syphilis and human immunodeficiency virus infection and microbiologic evidence of cervical infection with N...

The causative organism of gonorrhoea, Neisseria gonorrhoeae, has a special predilection for columnar epithelium. It is a delicate organism easily destroyed by heat, drying, mild antiseptics, and soap solutions. Transference of infection occurs when moist infective discharges come into contact with susceptible mucous membranes. Although the usual portal of entry of N. gonorrhoeae is the lower ge...

During infection, the sexually transmitted pathogen Neisseria gonorrhoeae (the gonococcus) encounters numerous host-derived antimicrobials, including cationic antimicrobial peptides (CAMPs) produced by epithelial and phagocytic cells. CAMPs have both direct and indirect killing mechanisms and help link the innate and adaptive immune responses during infection. Gonococcal CAMP resistance is like...

OBJECTIVES To determine aetiological factors associated with the prevalence of gonorrhoea in Ethiopian women to enable subsequent formulation of intervention policies. SUBJECTS 1851 Ethiopian women: 50% symptomatic, 50% asymptomatic. SETTING Gynaecological outpatient departments, antenatal, postnatal and family planning clinics (Ethiopian Family Guidance Association (EFGA)), in two teaching...

The recognition that attachment of pathogenic Neisseria to human mucosal surfaces involves specific interactions between polymeric filaments called pili and host cell receptors (1-4) has suggested new approaches to the immunoprophylaxis of meningococcal and gonococcal disease. Pili are present on meningococci and gonococci isolated from human mucosal surfaces (3, 4) and are found on meningococc...