The Na(+)/dicarboxylate cotransporter NaDC1 absorbs citric acid cycle intermediates from the lumen of the small intestine and kidney proximal tubule. No effective inhibitor has been identified yet, although previous studies showed that the nonsteroidal anti-inflammatory drug, flufenamate, inhibits the human (h) NaDC1 with an IC(50) value of 2 mM. In the present study, we have tested compounds r...

We present a rare case of bilateral anterior cerebral artery (ACA) territory infarction with akinetic mutism, quadriparesis and frontal lobe release signs along limbic dysfunction mimicking basilar thrombosis. The etiology was thrombosis the communicating propagation or embolism thrombus to both A2 segments restricted absent blood flow in branches arising from A3 causing extensive infarction. a...

PURPOSE To compare the precision of anterior chamber angle (ACA) and anterior chamber depth (ACD) measurements taken with ultrasound biomicroscopy (UBM) and the Artemis-2 Very High Frequency Ultrasound Scanner (VHFUS) in normal subjects. DESIGN Prospective study. METHODS We randomly selected one eye from each of 59 normal subjects in this study. Two subjects dropped out of the study; the as...

Peptide agonists and antagonists of both bradykinin (BK) B(1) and B(2) receptors (B(1)R, B(2)R) are known to tolerate to a certain level N-terminal sequence extensions. Using this strategy, we produced and characterized the full set of fluorescent ligands by extending both agonists and antagonist peptides at both receptor subtypes with 5(6)-carboxyfluorescein (CF) and the ε-aminocaproyl (ε-ACA)...

An analysis was made of clinical complications, determined with objective methods, in 68 patients at the University Clinic of Navarra with the clinical suspicion of antiphospholipid syndrome (APS) and presence of anticardiolipin antibodies (ACA). Patients with IgG higher than 23 GPL were considered for the study. The most prevalent pathology was thrombosis: venous thrombosis (42.6%) and arteria...

We studied 23 patients suffering cerebral ischemia who also had laboratory evidence of either a lupus anticoagulant (LA) or an abnormal anticardiolipin antibody (ACA). Four patients had lupus or a lupus-like illness, three had drug-induced lupus, and 16 had no overt evidence of collagen-vascular disease. Cerebral ischemic events were multiple in 71% of the patients; two patients presented with ...

This paper extends to pomsets without auto-concurrency the fundamental notion of asynchronous cellular automata (ACA) which was originally introduced for traces by Zielonka. We generalize to pomsets the notion of asynchronous mapping introduced by Zielonka and we show how to construct a deterministic ACA from an asynchronous mapping. Our main result generalizes Buchi's theorem for nite words t...

The purpose of the current study was to determine whether a tropical ginger derived compound 1'-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract ...

In this study, RAND Corporation researchers assess the expected change in enrollment and premiums in the Patient Protection and Affordable Care Act (ACA)-compliant individual market in federally facilitated marketplace (FFM) states if the U.S. Supreme Court decides to eliminate subsidies in FFM states. The analysis used the Comprehensive Assessment of Reform Efforts (COMPARE) microsimulation mo...

Statistical equations for inertial particle transport in turbulent boundary layers are usually closed using the quasi-Normal approximation (QNA), but this leads to large errors when inertia is significant. Here we develop a new closure based on an asymptotic solution exact equations, referred as ACA. Results show that ACA far better agreement with direct numerical simulation (DNS) data than QNA.