Cardiac complications such as arrhythmia and heart failure are common in Graves disease. Early detection and proper treatment of hyperthyroidism are important because cardiac complications are reported to be reversible if the thyroid function is normalized by medical treatment. We report here a case of cardiac complication of Graves disease that was too late to reverse with medical treatment an...

Hyperplastic changes of the thymus may be found in patients with Graves' disease. However, this rarely presents as an anterior mediastinal mass, particularly among adults. In this report, we describe a 46-year old woman with Graves' disease and thymic hyperplasia.

In four patients with euthyroid Graves' disease, serum T3 concentration and TRH response were tested. All four patients showed T3 concentration within normal range , albeit representing TRH-refractoriness. The results suggest the possibility that thyroid hormone concentration is not a sole determinant of TRH-responsiveness in Graves' disease, implying currently undetermined pathologic process u...

A rare case of resistance to thyroid hormone (RTH) complicated with Graves' hyperthyroidism was reported. The management of this disease is similar to that of Graves' disease. Antithyroid drug therapy is the first choice, and iodine therapy and surgery are not recommended due to the possibility of severe hypothyroidism and enlargement of the pituitary gland.

1Department of Endocrinology and Nutrition, Clinica Universidad de Navarra, 36 Pio XII Avenue, 31080 Pamplona, Spain 2Endocrine Unit, Evgenidion-Hospital, University of Athens, 11528 Athens, Greece 3Department of Medicine, C2 Link, University Hospital of Wales, Cardiff CF14 4XN, UK 4Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, James J. Peters VA Medical Center, New ...

Extraocular muscle biopsies from normal individuals and five patients with Graves' ophthalmopathy were analyzed by immunohistochemical staining. Fibroblasts in normal extraocular muscle as well as Graves' extraocular muscles expressed HLA-class II antigens, but the muscle cells did not. There was an increase of interstitial tissue in Graves' extraocular muscles but no visible damage to the musc...

BACKGROUND Thyrotoxicosis is both rarer and more severe in children than in adults, rendering management difficult and often unsatisfactory. OBJECTIVE To ascertain outcome in a geographically defined area of Scotland between 1989 and 2014. METHOD Retrospective case note review with follow-up questionnaire to family doctors for patients with Graves' disease and Hashimoto's thyroiditis. RES...

PURPOSE Treatment options in Graves' disease are clearly defined, but management practices and the perceptions of success are varied. The outcomes of treatment in large consecutive cohorts of Graves' disease have not been well characterised. The study describes the epidemiology, management strategies and medium term outcomes following anti-thyroid drug treatment, radio-iodine ablation and surge...

BACKGROUND Thyrotropin-producing pituitary tumor is relatively rare. In particular, concurrent cases associated with Graves' disease are extremely rare and only nine cases have been reported so far. We describe a case of a thyrotropin-producing pituitary adenoma concomitant with Graves' disease, which was successfully treated. CASE PRESENTATION A 40-year-old Japanese woman presented with mild...

Graves' disease with accompanying functioning nodules is known as Marine-Lenhart syndrome. Autonomously functioning thyroid nodules (AFTNs) also within Graves' thyroid tissue are almost always bening in nature. A 45-year-old man developed hyperthyroidism due to the coexistence of Graves' disease and AFTN. Total thyroidectomy was performed. The hyperfunctioning nodule with centrally hypoactive f...