نتایج جستجو برای: grn reverse engineering models
تعداد نتایج: 1233163 فیلتر نتایج به سال:
The spontaneous generation of an entire organism from a single cell is the epitome of a self-organizing, decentralized complex system. How do nonspatial gene interactions extend in 3-D space? In this work I present a simple model that simulates some biological developmental principles using an expanding lattice of cells. Each cell contains a genetic regulatory network (GRN), modeled as a feedfo...
Better understanding manual reverse engineering can make it and any associated systems reengineering more effective. We reverse engineered a version of a system (referred to as "BOS/X") in support of a broader reengineering effort. System reengineering goals and other circumstances dictated a focused, limited duration, manual reverse engineering exercise. This presented an opportunity to study ...
Gene regulatory networks (GRNs) are complex control systems that deal with the interaction of genes, which eventually control cellular processes at the protein level. The investigation of GRN provides huge information on cellular processes and gene functions and at last contributes to knowledge in genetics and in turn quality of life. By understanding the dynamics of these networks using correc...
VAQUISTA allows developers to reverse engineer a presentation model of a web page according to multiple reverse engineering options. The alternatives offered by these options not only widen the spectrum of possible presentation models but also encourage developers in exploring multiple reverse engineering strategies. The options provide filtering capabilities in a static analysis of HTML code t...
Nowadays the development without model-based approaches are hardly imaginable, because models are not only closer to human thinking but also help the communication between developers. During a long development process the initial model becames inconsistent with the code that can be synchronised manually or automatically by tools. Reverse engineering tools have been created to help developers ac...
Granulin (GRN) is a potent mitogen and growth factor implicated in many human cancers, but its regulation is poorly understood. Recent findings indicate that GRN is regulated strongly by the microRNA miR-107, which functionally overlaps with miR-15, miR-16, and miR-195 due to a common 5' sequence critical for target specificity. In this study, we queried whether miR-107 and paralogs regulated G...
OBJECTIVE To test whether rs1990622 (TMEM106B) is associated with age at onset (AAO) in granulin (GRN) mutation carriers and with plasma GRN levels in mutation carriers and healthy, elderly individuals. Rs1990622 (TMEM106B) was identified as a risk factor for frontotemporal lobar degeneration with TAR DNA-binding protein inclusions (FTLD-TDP) in a recent genome-wide association. DESIGN Rs1990...
Loss-of-function GRN mutations lead to GRN haploinsufficiency and consequently neurodegeneration with significant heterogeneity in clinical presentation of various syndromes. The aim of this study was to investigate the genetics and clinical features of patients with GRN-related frontotemporal lobar degeneration (FTLD) syndromes. We performed mutation analysis of GRN in 45 unrelated Canadian pa...
OBJECTIVE Consistent with the cognitive reserve hypothesis, higher education and occupation attainments may help persons with neurodegenerative dementias to better withstand neuropathology before developing cognitive impairment. We tested here the cognitive reserve hypothesis in patients with frontotemporal dementia (FTD), with or without pathogenetic granulin mutations (GRN+ and GRN-), and in ...
Heterozygous mutations in the GRN gene lead to progranulin (PGRN) haploinsufficiency and cause frontotemporal dementia (FTD), a neurodegenerative syndrome of older adults. Homozygous GRN mutations, on the other hand, lead to complete PGRN loss and cause neuronal ceroid lipofuscinosis (NCL), a lysosomal storage disease usually seen in children. Given that the predominant clinical and pathologica...
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