The splicing factor is important in cancer development, modulation numerous tumor suppressors and oncogenes, and regulation of multiple signaling pathways. Splicing factor 2/alternative splicing factor (SF2/ASF) is a proto‑oncogene, which has been implicated in the development of hepatocellular carcinoma. However, the underlying molecular mechanism remains to be elucidated. In the present study...

Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine. Since it reveals both proand anti-cancer properties (Balkwill et al., 2009), risk of malignancies in patients undergoing TNF-α antagonists therapy is always controversial. As our previous researches showed, breast cancer over-expressed TNF-α which played a vital role in the cancer’s occurrence and development, and we also found transmem...

interferon is a protein secreted by eucaryotic cells following stimulation by viruses, bacteria, and many other immunogenes. recent medical studies indicate that interferons have effective role in the treatment of virus infections, immunodeficiency and certain types of cancer such as hairy cell leukaemia (hcl). the aim of the present study is to apply yeast strain for secreting human ifnα2b fol...

AIM OF THE STUDY Many studies have shown that interferon-α (IFN-α) enhances the antiproliferative effect of gefitinib in some solid tumours. We aimed to determine the effect of combining IFN-α with gefitinib in human non-small cell lung cancer (NSCLC) cell lines (A549, H1299, HCC827) with different EGFR and K-Ras gene statuses. MATERIAL AND METHODS An MTT assay was used to assess cell prolife...

UNLABELLED Herpes simplex virus 1 (HSV-1) is a common human pathogen of clinical significance due to its association with vision impairment and encephalitis. In a mouse model of ocular neovascularization, we have previously shown that HSV-1 elicits the genesis of lymphatic vessels into the cornea proper through epithelial cell expression of vascular endothelial growth factor A (VEGFA) dependent...

Submit Manuscript | http://medcraveonline.com Abbreviations: R/M: Recurrent and/or Metastatic; HNSSC: Head and Neck Squamous Cell Carcinoma; FU: Fluorouracil; PFS: Progression-Free Survival; OS: Overall Survival; EGFR: Epidermal Growth Factor Receptor; TGF-α: Transforming Growth Factor-Alpha; TKI: Tyrosine Kinase Inhibitors; mAb: Monoclonal Antibodies; ACU: Area Under the Concentration; PD 1: P...

Received February 9, 2005; revision accepted for publication June 21, 2005. Correspondence: Misa Yamamoto, MT (Medical Technologist), CT (Cytologist), Faculty of Health Sciences, Yamaguchi University School of Medicine, MinamiKogushi 1-1-1, Ube, Yamaguchi, 755-8554, Japan. e-mail: [email protected] Fibrin Stimulates the Proliferation of Human Keratinocytes through the Autocrine Mechani...

Submit Manuscript | http://medcraveonline.com Abbreviations: R/M: Recurrent and/or Metastatic; HNSSC: Head and Neck Squamous Cell Carcinoma; FU: Fluorouracil; PFS: Progression-Free Survival; OS: Overall Survival; EGFR: Epidermal Growth Factor Receptor; TGF-α: Transforming Growth Factor-Alpha; TKI: Tyrosine Kinase Inhibitors; mAb: Monoclonal Antibodies; ACU: Area Under the Concentration; PD 1: P...