The binding of appropriate metal ions to linear ligand strands obtained by hydrazone polycondensations generates channel-like complexes by reversible coiling of the ligand, thus allowing the generation of ion-induced, acid-base neutralisation fueled, molecular nanomechanical contraction/extension motions of large amplitude.

The title hydrazone compound, C(14)H(10)ClFN(2)O, adopts an E configuration about the C=N double bond. The dihedral angle between the two substituted benzene rings is 11.6 (2)°. The F atom is disordered over two sites with occupancies of 0.488 (2) and 0.512 (2). In the crystal, mol-ecules are linked through inter-molecular N-H⋯O hydrogen bonds, forming chains along the a axis. C-H⋯F and C-H⋯O i...

Temperature-sensitive mutants in the RCC1 gene of BHK cells fail to maintain a correct temporal order of the cell cycle and will prematurely condense their chromosomes and enter mitosis at the restrictive temperature without having completed S phase. We have used Xenopus egg extracts to investigate the role that RCC1 plays in interphase nuclear functions and how this role might contribute to th...

The adenylate cyclase activity of crude membranes prepared from Chinese Hamster Ovary (CHO) cells in culture is enhanced about a-fold with 0.1 mM GTP and 5to lo-fold with 0.1 mu guanyl-V-y1 imidodiphosphate (Gpp(NH)p). Incubation of intact CHO cells with cholera toxin results in pronounced activation of adenylate cyclase, and this activated form of the enzyme is also stimulated by GTP and Gpp(N...

Adenylate cyclase activity in Xenopus oocyte membranes measured in the presence of guanyl-5'-yl imidodiphosphate and 1.5 mM Mn2+ was maximally inhibited to 57% of control by progesterone and to 89% by the P site agonists, 2',5'-dideoxyadenosine and 9-beta-d-arabinofuranosyladenine. Inhibition by saturating concentrations of 2',5'-dideoxyadenosine and progesterone was not additive, suggesting th...

1,2,4-Triazoles are important heterocyclic motifs that widely found in molecular architectures with medicinal and pharmaceutical properties. Considering the importance of these scaffolds, many works have been published over last few decades. This review provides a focus on synthetic approaches towards 1,2,4-triazole derivatives from common precursors such as amidines, imidates, amidrazones, ary...

Aflatoxin B1 and benzo(a)pyrene were activated by both cultured human bronchus and human colon as measured by binding to cellular DNA and protein. The binding of aflatoxin B1 to DNA was dose dependent, and the level of binding was higher in cultured human bronchus than it was in the colon. When compared to aflatoxin B1, the binding level of benzo(a)pyrene to both bronchial and colonic DNA was g...

Several types of basic compounds structurally related to spermidine, one of the substrates for deoxyhypusine synthase, were tested as inhibitors of this enzyme. The results indicate that inhibitory compounds associate with the enzyme at the site of spermidine binding and must possess two charged primary amino or guanidino groups, or one of each. The efficiency of inhibition is related to the ma...