n the nervous system, guidance molecules called semaphorins bind to receptors called plexins to induce motility and regulate axonal pathfinding. Now, Swiercz et al. (page 869) show that plexin-B1, after binding its ligand semaphorin 4D (Sema4D), forms a heterodimer with the tyrosine kinase ErbB2. This raises the intriguing possibility that the semaphorins and the EGF-like ligands of ErbB recept...

Many homilies have been preached on " life's failures "?who are generally visualized as grimy loafers supporting die walls of a public house. But failures are of many types and they are not always recognizable at sight. They include the adventurous spirit eating out his heart as a bank clerk; the Army officer whose heart is in Cambridge or Bloomsbury and who finds nothing but boredom in his wor...

there is a disagreement among scholars over the meaning of abraham’s leadership mentioned in the quran, 2, 124. in this connection, allamatabatabaee presents an innovative opinion and interprets leadership as guidance by the command (al-hidaya bi’l amr) since imam is qualified by guidance by the command as if the qualification is to describe the meaning of leadership (imamat). in allama’s opini...

Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery that would allow the local synthesis of receptors for axon guidance cues.

It is easy for the psychiatrist to refer young patients who come his way to a child guidance clinic, and this is done regularly. With adolescents who are too old for child guidance treatment, and who are not old enough to be sent to an ordinary clinic for treating nervous disorders in adults, there is a problem of considerable magnitude, and it is specially to this, and to the large influence o...

The Roundabout ("Robo") family of transmembrane proteins are the receptors and mediators of the repellent axon guidance signal Slit. However, the molecular mechanisms by which Robo signaling leads to growth cone or neuron repulsion are still poorly understood. A study by Fan et al. in this issue of Neuron expands the repertoire of Robo pathway components and stimulates a new look at axon guidan...

Precise patterning of axon guidance cue distribution is critical for nervous system development. Using a murine forward genetic screen for novel determinants of axon guidance, we identified B3gnt1 and ISPD as required for the glycosylation of dystroglycan in vivo. Analysis of B3gnt1, ISPD, and dystroglycan mutant mice revealed a critical role for glycosylated dystroglycan in the development of ...

11 Abstract In this paper, we present the results of an exploratory study into the relationship 12 between student self-efficacy and guidance use in a Multi-User Virtual Environment 13 (MUVE) science curriculum project. We describe findings from a sample of middle school 14 science students on the combined impact on learning of student self-efficacy in scientific 15 inquiry and use of individua...