1 2 3 4 5 6 7 8 Quantitative and Functional Interrogation of Parent-of-Origin 9 Allelic Expression Biases in the Brain 10 11 Julio D. Perez, Nimrod D. Rubinstein, Daniel E. Fernandez, Stephen W. Santoro, 12 Leigh A. Needleman, Olivia Ho-Shing, John J Choi, Mariela Zirlinger, Shau-Kwaun 13 Chen, Jun S. Liu, Catherine Dulac* 14 Department of Molecular and Cellular Biology, Harvard University, How...

A 20-year-old man with a history of congenital central hypoventilation syndrome presented with recent-onset psychosis, catatonia, and a diagnosis of schizophrenia. Psychiatric symptoms were resistant to conventional treatment. A fluorodeoxyglucose positron emission tomography scan of the brain obtained during the hospitalization revealed a hypometabolism distribution more consistent with hypope...

PAirwise Sequence Comparison (PASC) is a tool that uses genome sequence similarity to help with virus classification. The PASC tool at NCBI uses two methods: local alignment based on BLAST and global alignment based on Needleman-Wunsch algorithm. It works for complete genomes of viruses of several families/groups, and for the family of Filoviridae, it currently includes 52 complete genomes avai...

The problem of assembling DNA fragments starting from imperfect strings given by a sequencer, classified as NP-hard when trying to get perfect answers [4], has a huge importance in several fields, because of its relation with the possibility of detecting similarities between animals, dangerous pests in crops, and so on. Some of the algorithms and data structures that have been created to solve ...

The simulation of high-rate deformation and failure of metals is has traditionally been performed using Lagrangian finite element methods or Eulerian hydrocodes. Lagrangian mesh-based methods are limited by issues involving mesh entanglement under large deformation and considerable complexity in handling contact. On the other hand, Eulerian hydrocodes are prone to material diffusion. In the Mat...

A novel numerical approach to analyze the mechanical behavior within composite materials including inelastic regime up final failure is presented. Therefore, a second-gradient theory combined with phase-field methods fracture. In particular, we assume that polymeric matrix material undergoes ductile fracture, whereas continuously embedded fibers undergo brittle fracture as it typical e.g. for r...

The performance of the many-core Tile64 versus the multi-core Xeon x86 architecture on bioinformatics has been compared. We have used the pairwise algorithm MC64-NW/SW that we have previously developed to align nucleic acid (DNA and RNA) and peptide (protein) sequences for the benchmarking, being an enhanced and parallel implementation of the Needleman-Wunsch and Smith-Waterman algorithms. We h...

The use of a priori knowledge in the alignment of targeted sequencing data is investigated using computational experiments. Adapting a Needleman-Wunsch algorithm to incorporate the genomic position information from the targeted capture, we demonstrate that alignment can be done to just the target region of interest. When in addition use is made of direct string comparison, an improvement of up ...

This paper presents a Modified Dynamic Parallel Algorithm for Sequence Alignment in BioSequences. DNA sequence alignment between two or more bio sequences using algorithms is a complex problem due to its applicability in the field of biology. This algorithm achieves its efficiency in using computational resources by making a M X N matrix , M represents the length of first sequence and N represe...