BACKGROUND This study was performed to assess the impact of irradiation on the tissue penetration depth of doxorubicin delivered during Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC). METHODS Fresh post mortem swine peritoneum was cut into 10 proportional sections. Except for 2 control samples, all received irradiation with 1, 2, 7 and 14 Gy, respectively. Four samples received PIP...

OBJECTIVE To evaluate irradiation toxic effects from fluoroscopy during intra-arterial chemotherapy for retinoblastoma. DESIGN Prospective trial. PARTICIPANTS Eight patients treated with intra-arterial chemotherapy. MAIN OUTCOME MEASURES Irradiation toxic effects in vital organs. RESULTS The mean patient age was 29 months (range, 10-74 months) and 63% were male. The mean irradiation dos...

Abstract The aim of this study was to investigate secondary metabolite production in Silybum marianum L. cell suspension cultures obtained from seeds treated with gamma rays (200 and 600 Gy) 0.05% colchicine. effects these treatments on callus induction, growth, viability, silymarin were studied, along the changes transcriptome DNA sequence chalcone synthase (CHS) genes. effect radiation S. dry...

Breeding maize with high contents of zinc, iron and provitamin A (PVA) could be effective in mitigating micronutrient deficiency developing countries a reliance on maize-based diets. Information the mode inheritance iron, PVA grain yield (GY) would facilitate development varieties enhanced these nutrients. Twenty-four yellow to orange inbred lines their 96 F1 hybrids generated using North Carol...

During radiotherapy, ionizing irradiation interacts with biological systems to produce free radicals, which attacks various cellular components. The hematopoietic system is well-known to be radiosensitive and its damage may be life-threatening. Melatonin synergistically acts as an immunostimulator and antioxidant. In this study we used a total of 120 rats with 20 rats in each group. Group 1 did...

BACKGROUND AND PURPOSE Radiation-induced cognitive dysfunction is a common and serious complication after radiation therapy of brain tumor, yet knowledge of its mechanism is poorly understood. The aim of this study was to establish a young rat model for acute radiation encephalopathy, at both cognitive and pathologic levels, induced by fractionated irradiation. MATERIALS AND METHODS Four-week...

PURPOSE To investigate the correlation between diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) derived parameters and radioresponsiveness of Lewis lung carcinoma (LLC) tumor. MATERIALS AND METHODS LLC tumor growth in C57BL/6 mouse limb was used for the experiment. The tumors were irradiated with 10 Gy×5, or 30 Gy×2 vs. sham irradiation. Fourteen tu...

BACKGROUND To make a radiobiological comparison, for high risk prostate cancer (T3a, PSA > 20 ng/ml or Gleason > 7) of two radiotherapy treatment techniques. One technique consists of a treatment in three phases of the pelvic nodes, vesicles and prostate using a conventional fractionation scheme of 2 Gy/fraction (SIMRT). The other technique consists of a treatment in two phases that gives simul...