When tested against 254 Haemophilus influenzae strains, LBM415, a peptide deformylase inhibitor, gave MIC50 and MIC90 values of 2.0 microg/ml and 8.0 microg/ml, respectively. The MICs were independent of beta-lactam or quinolone susceptibility and the presence or absence of macrolide efflux or ribosomal protein mutations. The MICs of LBM415 against 23 H. parainfluenzae strains were similar to t...

Streptococcus pneumoniae eta Haemophilus influenzae bakterio espezieek eragindako infekzioek prebalentzia handia dute, infekzio inbaditzaileek koadro larriak dakartzatelarik. Prebentziorako estrategia nagusia txertaketa da. Txerto pneumokoziko konjugatuak (PCV; ingelesezko sigla) b motako H. influenzae-ren (Hib) aurkako txertoak haurren txertaketa-egutegian ezarrita daude. polisakaridiko pneumo...

A case is reported of polytenosynovitis in a 31-year-old male during the course of a severe bacteraemic illness caused by Haemophilus influenzae type b. The clinical presentation was similar to tenosynovitis caused by bacterial or viral agents. As the management of the H. influenzae tenosynovitis would differ from that due to other causes, the addition of H. influenzae type b to a differential ...

Autotransporters are a large class of proteins that are found in the outer membrane of Gram-negative bacteria and are almost universally implicated in virulence. These proteins consist of a C-terminal β-domain that is embedded in the outer membrane and an N-terminal domain that is exposed on the bacterial surface and is endowed with effector function. In this article, we review and compare the ...

In this study we isolated the pilin gene from the Brazilian purpuric fever (BPF) clone of Haemophilus influenzae biogroup aegyptius, expressed the gene in Escherichia coli, and determined its nucleotide sequence. Comparison of the nucleotide sequence of the BPF pilin gene with the sequences of pilin genes from strains of H. influenzae sensu stricto demonstrated a high degree of identity. Consis...

BACKGROUND Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes, and Streptococcus pneumoniae are the most common causative agents of respiratory tract infections (RTIs). The increase in resistance to current antibacterial agents highlights the need to monitor the resistance pattern of these bacterial pathogens. METHODOLOGY In this study, we assessed the antibacterial suscept...

Haemophilus influenzae penetrates between epithelial cells via an unknown mechanism. A chromosomal library of nonencapsulated H. influenzae strain A960053 DNA was constructed in Escherichia coli DH5alpha to identify bacterial genes contributing to this paracytosis. Two E. coli clones that contained open reading frames (ORFs) homologous to HI0636 to HI0641 of H. influenzae strain Rd and that sho...

During antibiotic therapy for serious Haemophilus influenzae type b infections in children, respiratory mucosal colonization with this organism is suppressed but not eradicated. To define possible mechanisms contributing to this suppression, the ability of six antibiotics to influence the adherence of H. influenzae type b to human epithelial cells was investigated. In assays in which the organi...

CONTEXT The introduction of Haemophilus influenzae type b (Hib) vaccination of children has led to a decline in incidence of Hib disease in young Alaskan children. However, the impact of vaccination on unimmunized Alaskan adolescents and adults has not been studied. OBJECTIVE To characterize trends in incidence of and mortality due to invasive H influenzae disease in Alaskan residents aged 10...

Haemophilus influenzae type b causes more than 95% of serious H. influenzae meningitis. H. influenzae type e (Hie) has been implicated in a few cases of meningitis. Here, we present an adult Saudi patient with Hie meningitis and review the literature. The patient, a 19-year-old Saudi male with no significant past medical history, was noted by his family to have some changes in his mentation, co...