نتایج جستجو برای: h2ax gene
تعداد نتایج: 1142668 فیلتر نتایج به سال:
Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR). As neurons have high rates of transcription that require topoisomerase I (TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent transcription-blocking lesions-also produce transcription-dependent DNA double-st...
The rapid accumulation of signaling and repair factors in the vicinity of DNA lesions is an integral part of the cellular DNA damage response (DDR) to DNA double-strand breaks (DSBs).1,2 This is initiated by posttranslational modifications of core histones, to which various effector proteins bind. The priming modification is ATM-mediated phosphorylation of histone H2AX at Ser-139 (γ-H2AX), a ma...
The rapid accumulation of signaling and repair factors in the vicinity of DNA lesions is an integral part of the cellular DNA damage response (DDR) to DNA double-strand breaks (DSBs).1,2 This is initiated by posttranslational modifications of core histones, to which various effector proteins bind. The priming modification is ATM-mediated phosphorylation of histone H2AX at Ser-139 (γ-H2AX), a ma...
Ataxia telangiectasia (A-T) is a progressive neurodegenerative disease with onset in early childhood, caused by mutations in the ATM (ataxia-telangiectasia mutated) gene. Diagnosis relies on laboratory tests showing high levels of serum alphafetoprotein, cell sensitivity to ionizing radiation (IR) and absence or reduced levels of ATM protein. Many tests, however, are not sufficiently sensitive ...
Abstract Background DNA damage response plays critical roles in tumor pathogenesis and radiotherapy resistance. Protein phosphorylation is a mechanism regulation of response; however, the key mediators for radiosensitivity gastric cancer still needs further exploration. Methods A quick label-free phosphoproteomics using high-resolution mass spectrometry an open search approach was applied to pa...
Agents that induce DNA double-strand breaks (DSBs), such as ionizing radiation, are frequently used in cancer therapy. H2AX is rapidly phosphorylated in response to DSBs and serves as a way to measure the extent of DSBs induced in patient cells. We have previously reported a flow cytometry-based method for measuring H2AX phosphorylation in patient cells undergoing radiotherapy. To be able to im...
When mammalian cell cultures or mice are exposed to ionizing radiation in survivable or lethal amounts, novel mass components are found in the histone H2A region of two-dimensional gels. Collectively referred to as gamma, these components are formed in vivo by several procedures that introduce double-stranded breaks into DNA. gamma-Components, which appeared to be the only major novel component...
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