BACKGROUND Hydrogen peroxide (H2O2) and reactive oxygen species are implicated in inflammation, ischemia-reperfusion injury, and atherosclerosis. The role of ion channels has not been previously explored. METHODS AND RESULTS K+ currents and membrane potential were recorded in endothelial cells by voltage- and current-clamp techniques. H2O2 elicited both hyperpolarization and depolarization of...

We previously showed that hydrogen peroxide (H2O2) induced resistance artery relaxation independent of endothelium. Thus, in this study we investigated the mechanism of relaxation induced by H2O2 on human renal vascular smooth muscle cell (HVSMC). HVSMC were stimulated with H2O2 and/or angiotensin II (Ang II), proline-rich-tyrosine-kinase-2 (PYK2), ERK1/2 MAP-Kinase, and myosin light chain 20 p...

Reactive oxygen species produce oxidized bases, deoxyribose lesions and DNA strand breaks in mammalian cells. Previously, we demonstrated that aldehydic DNA lesions (ADLs) were induced in mammalian cells by 10 mM hydrogen peroxide (H2O2). Interestingly, a bimodal H2O2 dose-response relationship in cell toxicity has been reported for Escherichia coli deficient in DNA repair as well as Chinese ha...

BACKGROUND Reactive oxygen species play critical roles in homeostasis and cell signaling. Dexmedetomidine, a specific agonist of the α2-adrenoceptor, has been commonly used for sedation, and it has been reported to have a protective effect against oxidative stress. In this study, we investigated whether dexmedetomidine has a protective effect against H2O2-induced oxidative stress and the mechan...

bis-(l-tyrosinato)copper(ii) was reacted with 3-(chloropropyl)-trimethoxysilane functionalized silica that has infused magnetite to yield a magnetically separable catalyst in which the copper carboxylate is covalently linked to the silica matrix through the silane linkage. the immobilized catalyst has been characterized by spectroscopic studies (such as ft-ir, epr, magnetic measurement, sem) an...

This paper reports on the response of a fiber-optic sensing probe to small concentrations of hydrogen peroxide (H2O2) vapor at room temperature. H2O2 has extensive applications in industrial and medical environments. Conversely, H2O2 can be a health hazard by itself. For example, H2O2 induces cellular damage in human cells and its presence can be used to diagnose illnesses such as asthma and hu...

to evaluate the effects of seed priming with salicylic acid on quality and baking traits of wheat flour, cv. alvand, under different sowing dates, a factorial experiment was conducted on the basis of complete randomized block design. the factors were seed priming with salicylic acid (including untreated seeds or control treatment, 400, 800, 1200, 1600, 2000 and 2400 µm concentrations of salicyl...

effects of seed priming by salicylic acid on some morpho-physiologic characteristics and yield of cowpea (vigna unguiculata l.) cultivar “parastou” was investigated under water deficit. experiment was conducted as a split block design with 3 replications in 2008-2009 at research farm of zanjan university. factors were including drought stress as a main factor in 2 levels (irrigation, water defi...

Cadmium (Cd) is considered one of the most toxic heavy metals to living organisms, being very persistent in soil and non-biodegradable, thus posing a long-term hazard plants humans. In recent years, application different molecules at seed level, known as chemical priming, has been studied method improve stress tolerance plants. present study, we tested effect hydro-priming proline priming lettu...