Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevents the loss of iron and subsequent kidney damage following hemolysis. In human, the Hp locus is polymorphic with two co-dominant alleles (Hp1 & Hp2) that yield three distinct genotype/ phenotype (Hp 1-1, Hp 2-1, Hp 2-2).The haptoglobin phenotype of Indian patients of malari...

ECENTLY much attention has been focused on the protein binding of hemoglobin. The hemoglobin binding proteins, collectively called haptoglobin, have been thoroughly studied by several workers.’5 Indentification of these substances has helped to clarify the concept of “renal threshold” for hemoglobin excretion.5’6’9 Subsequently, in an investigation of the difference in “renal threshold” of myog...

Male BALB/c mice were infected with a single cercarial dose of Schistosoma mansoni and later treated curatively with praziquantel on Day 42 post-infection. Serum from the animals was studied for changes in concentration of haptoglobin, albumin, iron, zinc and copper. The infection resulted in significant decreases in serum albumin, iron and zinc, and increases in serum haptoglobin and copper. H...

BACKGROUND Allergic rhinitis (AR) is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. Different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis. OBJECTIVE To investigate association of haptoglobin (Hp) phenotypes (Hp1-1, 2-1 and 2-2) with serum immunoglobulins A and E levels ...