In a screen for early developmental mutants of the zebrafish, we have identified mutations specifically affecting the internal organs. We identified 53 mutations affecting the cardiovascular system. Nine of them affect specific landmarks of heart morphogenesis. Mutations in four genes cause a failure in the fusion of the bilateral heart primordia, resulting in cardia bifida. In lonely atrium, n...

We present a case of a probably unnecessary Caesarean section due to misinterpretation of the cardiotocography (CTG) trace during general anaesthesia. A 27-yr-old patient in her 30th week of an uneventful, normal first pregnancy presented with a deep venous thrombosis in the pelvic region. She was to undergo an emergency thrombectomy under general anaesthesia. During the operation, the CTG show...

Driver drowsiness is one of the major causes of serious traffic accidents, which makes this an area of great socioeconomic concern. Continuous monitoring of drivers’ drowsiness thus is of great importance to reduce drowsiness-caused accidents. This proposed research developed a real-time, nonintrusive driver drowsiness detection system by building biosensors on the automobile steering wheel and...

We present generalizations of our previously published artificial models for generating multi-channel ECG to provide simulations of abnormal cardiac rhythms. Using a three-dimensional vectorcardiogram (VCG) formulation, we generate the normal cardiac dipole for a patient using a sum of Gaussian kernels, fitted to real VCG recordings. Abnormal beats are specified either as perturbations to the n...

UNLABELLED The objective of this study was to investigate the effect of beta blocker on cardiac recovery and rhythm during cardiac surgeries. Sixty surgical rheumatic heart disease patients were received esmolol 1 mg/kg or the same volume of saline prior to removal of the aortic clamp. The incidence of cardiac automatic re-beat, ventricular fibrillation after reperfusion, the heart rate after s...

We propose and evaluate an unsupervised method for the estimation of heart rate variability (HRV) indices from ballistocardiograms (BCGs) recorded by a bed-mounted, electromechanical film (EMFi) sensor during sleep. After estimating the beat-to-beat intervals from the BCGs, short-term timeand frequency-domain HRV indices are computed and compared to an ECG reference. We evaluated signals record...

In this work a blood pressure and heart rate variability estimation system is presented. Instead of merely using beat-to-beat time interval extracted from the electrocardiogram (ECG), it is also used finger photoplethysmography (PPG) and ballistocardiography (BCG) information to have three independent estimates of the heart rate variability. Since pulse arrival and transit times can be extracte...

We have examined in eight male volunteers the effect of midazolam sedation on the relationship between timing of spontaneous ventilations and heart beat. On 2 study days, subjects received either midazolam 0.1 mg kg-1 or saline placebo while recordings were made of ECG and ventilatory impedance pneumography. We observed in all midazolam-treated subjects clear evidence of synchronous or non-sync...

Electrocardiogram (ECG) is used to assess the heart arrhythmia. Accurate detection of beats helps determine different types of arrhythmia which are relevant to diagnose heart disease. Automatic assessment of arrhythmia for patients is widely studied. This paper presents an ECG classification method for arrhythmic beat classification using RR interval. The methodology is based on discrete cosine...

This study evaluates influence of increased heart rate on beat-to-beat variability of vector magnitude depolarisation signal in patients admitted for cardiac electrophysiology studies. Electrical variability is quantitatively assessed during normal sinus rhythm and during atrial pacing by means of the Morlet wavelet transform variance in high-frequency region of 100Hz to 250Hz. Results suggest ...